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首页> 外文期刊>ANZ journal of surgery >Clinical value of preoperative CA19‐9 levels in evaluating resectability of gallbladder carcinoma
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Clinical value of preoperative CA19‐9 levels in evaluating resectability of gallbladder carcinoma

机译：术前Ca19-9水平评估胆囊癌重新分配的临床价值

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摘要

Background This study evaluated the predictive ability of preoperative carbohydrate antigen 19‐9 (CA19‐9) level in assessing tumour resectability in patients with gallbladder carcinoma (GBC). Methods We retrospectively analysed preoperative serum levels of CA19‐9 in 292 patients with potentially resectable GBC between January 2000 and March 2016 in our institution. All final diagnoses were confirmed by pathological examination. The optimal cut‐off point of the CA19‐9 for predicting resectability was determined by the receiver operating characteristic curve. The univariate analysis and multivariate Cox regression model were applied to assess the relationship between the parameters to resectability. Results A total of 292 patients with surgical treatment were included, of whom 195 were identified as curative resection (R0 resection), 69 were classified as R1/2 resection and the remaining 28 patients were operated on with palliative surgery. The receiver operating characteristic curve analysis calculated the best CA19‐9 cut‐off point of 98.91?U/mL in the prediction of resectability. Meanwhile, the sensitivity, specificity, positive predictive value and negative predictive value were 76.3%, 70.8%, 85.7% and 56.5%, respectively. In the multivariate logistic regression analysis, CA19‐9?98.91?U/mL (odds ratio (OR) 6.339, 95% confidence interval (CI) 3.562–11.284, P ??0.001), tumour located on hepatic side (OR 1.787, 95% CI 1.022–3.123, P ?=?0.042) and advanced American Joint Committee on Cancer stage (OR 2.156, 95% CI 1.180–3.940, P ?=?0.013) were independent determinants of resectability in patients diagnosed as GBC. Conclusion Preoperative CA19‐9 predicts resectability in patients with radiological resectable GBC. Increased preoperative CA19‐9 is related to poor resectability rate.
机译：背景技术本研究评估了术前碳水化合物抗原19-9（CA19-9）水平评估胆囊癌（GBC）患者肿瘤重新入学的预测能力。方法介绍在2000年1月至2016年3月在我们的机构在2016年1月至2016年3月潜在的292名患者术前分析了CA19-9的术前血清水平。通过病理检查证实了所有最终诊断。 CA19-9的最佳截止点用于预测重置性的通过接收器操作特性曲线确定。应用单变量分析和多变量COX回归模型来评估参数之间的关系。结果总共292例外科治疗患者，其中195例被鉴定为治疗切除（R0切除术），69例被归类为R1 / 2切除术，剩余的28名患者用姑息手术进行操作。接收器操作特性曲线分析计算了预测重新切性的最佳CA19-9截止点98.91的截止点。同时，敏感性，特异性，阳性预测值和负预测值分别为76.3％，70.8％，85.7％和56.5％。在多变量逻辑回归分析中，Ca19-9？＆ 98.91？U / ml（OTS比（或）6.339,95％置信区间（CI）3.562-11.284，p≤≤0.001），位于肝侧的肿瘤（或1.787,95％CI 1.022-3.123，P？= 0.042）和先进的美国癌症阶段联合委员会（或2.156,95％CI 1.180-3.940，p？= 0.013）是诊断患者的重症性的独立决定因素作为GBC。结论术前CA19-9预测放射性转型GBC患者的重新分析。增加的术前CA19-9与可释放性率不佳有关。

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  • 来源
    《ANZ journal of surgery》 |2019年第3期|共5页
  • 作者

    Liu Fei; Wang Jun‐Ke; Ma Wen‐Jie; Yang Qin; Hu Hai‐Jie; Li Fu‐Yu;

  • 作者单位

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

    Department of Biliary SurgeryWest China Hospital of Sichuan UniversityChengdu China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 外科学;
  • 关键词

    carbohydrate antigen 19‐9; gallbladder carcinoma; resectability;

    机译：碳水化合物抗原19-9;胆囊癌;重症性;

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