...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Surgical Pathology >Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation Report of a Series With Detailed Immunohistochemical Analysis
【24h】

Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation Report of a Series With Detailed Immunohistochemical Analysis

机译：初级阴道胃型腺癌和阴道肾病呈胃分化报告，具有详细免疫组化分析

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

So-called gastric-type adenocarcinoma and related premalignant lesions have been characterized in the cervix, but similar lesions are not widely recognized in the vagina. We report a series of 11 vaginal glandular lesions exhibiting gastric differentiation, comprising 5 cases of adenocarcinoma and 6 of adenosis. All cases occurred in adults (aged 33 to 69) with no known history of diethylstilboestrol exposure. The vaginal adenocarcinomas exhibited morphologic features identical to gastric-type adenocarcinoma of the cervix, but 1 case additionally demonstrated basaloid and sarcomatoid components, which have not been previously reported in cervical gastric-type adenocarcinoma. Immunohistochemically, the adenocarcinomas were positive for MUC6 (4/5), PAX8 (3/5), CK7 (5/5), CK20 (1/5), CDX2 (5/5), CA19.9 (5/5), CEA (4/5), CA125 (5/5), and hepatocyte nuclear factor 1 (5/5). p16, estrogen receptor, and Napsin A were negative in all cases tested, whereas p53 exhibited mutation-type staining in 3/5 cases. In all 5 adenocarcinomas, a component of adenosis with benign or atypical nuclear features was identified; the adenosis displayed gastric morphology in 4 cases and tuboendometrial morphology in 1. The 6 cases of pure vaginal adenosis (without associated adenocarcinoma) all contained gastric-type mucinous glands together with tuboendometrial glands in 2 cases. There was focal intestinal differentiation with goblet cells in all 6 cases and neuroendocrine cells with eosinophilic granules in 3. Cytologic atypia was observed in 4/6 cases of pure vaginal adenosis. Immunohistochemically, the gastric-type adenosis (10 cases) was positive for MUC6 (10/10), estrogen receptor (5/10), PAX8 (8/10), CK7 (9/9), CK20 (2/9), CDX2 (5/9), CA19.9 (8/9), CEA (6/9), CA125 (6/9), hepatocyte nuclear factor 1 (10/10), and Napsin A (1/10). p53 exhibited wild-type immunoreactivity in all 10 cases, whereas p16 was negative in all cases tested. Scattered individual chromogranin-positive cells were present in all 5 cases of pure adenosis tested. Follow-up was available in 4 of the adenocarcinoma cases, with 3 patients dead of disease within 1 to 3 years and 1 patient alive with disease at 1 year. The morphologic and immunohistochemical findings in our study suggest a close relationship between vaginal gastric-type adenocarcinoma and adenosis exhibiting gastric differentiation. This probably represents a distinct pathway of vaginal gastric-type carcinogenesis analogous to that occurring in the cervix. We propose that gastric-type adenocarcinoma be recognized as a distinct histologic subtype of vaginal adenocarcinoma while vaginal adenosis of gastric-type represents a novel subtype of adenosis that requires further study to clarify its biological potential.
机译：所谓的胃型腺癌和相关的预先发生病变已经表征在子宫颈中，但在阴道中没有广泛识别类似的病变。我们报告了一系列11种阴道腺体病变，其表现出胃分化，包括5例腺癌和6例腺癌。所有病例均发生在成人（年龄33至69岁）中，没有已知的二乙基雌甾醇暴露的历史。阴道腺癌表现出与子宫颈胃型腺癌相同的形态特征，但是另外展示了患有宫颈胃型腺癌中未报道的碱性和SARCAMATOID组分的1例。免疫组织化学，腺癌为MUC6（4/5），PAX8（3/5），CK7（5/5），CK20（1/5），CDX2（5/5），CA19.9（5/5）呈阳性，CEA（4/5），Ca125（5/5）和肝细胞核因子1（5/5）。在所有测试的所有病例中，P16，雌激素受体和鼻内A都是阴性的，而P53在3/5例中表现出突变型染色。在所有5个腺癌中，鉴定了良性或非典型核特征的腺度腺度成分;腺度暗指在4例中显示出胃形态和油管形态。纯阴道腺苷病（无相关腺癌）的6例，所有含有胃型粘膜腺体，在2例中与管腔腺体一起。在所有6例患者中，在纯阴道腺炎的4/6例中观察到具有嗜酸性粒细胞颗粒的所有6例和神经内分泌细胞的泌尿膜细胞。免疫组织化学，胃型腺眼症（10例）对于MUC6（10/10），雌激素受体（5/10），PAX8（8/10），CK7（9/9），CK20（2/9）， CDX2（5/9），Ca19.9（8/9），CEA（6/9），Ca125（6/9），肝细胞核因子1（10/10）和瘤瘤A（1/10）。 P53在所有10例患者中表现出野生型免疫反应性，而P16在所有测试的情况下是阴性的。在所有5例纯腺度测试中存在分散的单独的染色体阳性细胞。随访中有4例腺癌病例，3例患者在1至3年内死亡，1名患者在1年内患有疾病。我们研究中的形态学和免疫组织化学发现表明阴道胃型腺癌和腺度模糊腺瘤之间的密切关系。这可能代表类似于在子宫颈中发生的阴道胃型致癌物的明显途径。我们提出胃型腺癌被认为是阴道腺癌的明显组织学亚型，而胃型的阴道腺腺度腺度腺苷是一种腺度腺炎，需要进一步研究以阐明其生物潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号