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首页> 外文期刊>Appetite >Exclusively drinking sucrose or saline early in life alters adult drinking behavior by laboratory rats
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Exclusively drinking sucrose or saline early in life alters adult drinking behavior by laboratory rats

机译：专注于生活早期饮用蔗糖或盐水改变了实验室大鼠的成人饮酒行为

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摘要

Proper fluid balance is critical for life. Learning plays an important role in shaping the appetitive behaviors required for drinking. Children often forego drinking plain water and instead consume beverages such as milk or juice. What effect this may have on adult thirst responses remains an open question. To model aspects of the human condition, we bred Sprague-Dawley rats and prevented the pups from obtaining fluid other than from nursing. Pups were weaned onto either tap water, 5% sucrose, or 0.45% saline, and given access to only that fluid for at least 7 weeks. We then measured intake of water or sucrose/saline in one-bottle tests after mild hypertonic saline (HS) injection, or overnight fluid deprivation, and in two-bottle tests after HS injection while rats were maintained on their respective fluids, and after all subjects had only water to drink for a week. We found that sucrose- and saline-maintained rats drank less water than did controls after the HS challenge. After overnight fluid deprivation, rats maintained on saline drank less water and more saline, but there was no difference in intake between water-maintained and sucrose-maintained rats. Differences in licking patterns, including more licks/burst for sucrose by sucrose-maintained rats were detected, even in cases when total intake was not different. These data provide evidence that adult rat water intake can be reduced by exclusively drinking sucrose or saline early in life.
机译：适当的流体平衡对于寿命至关重要。学习在塑造饮酒所需的快速行为方面发挥着重要作用。孩子们经常放弃饮用普通水，而是消耗牛奶或果汁等饮料。在成人口渴的反应上可能对此有何影响仍然是一个开放的问题。为了模拟人体状况的方面，我们培育了Sprague-Dawley大鼠并防止了幼崽获得除护理以外的流体。幼崽被断奶浸渍在自来水，5％蔗糖或0.45％盐水上，并允许仅进入该液体至少7周。然后在轻度高渗盐水（HS）注射或过夜液体剥夺后，在单瓶试验中测量水或蔗糖/盐水的摄入量，或在HS注射后的两瓶试验中，但在其各自的流体上保持大鼠，毕竟受试者只有一周的水喝水。我们发现蔗糖和盐水维持的大鼠比HS挑战后的控制少喝水。过夜液体剥夺后，维持在盐水上的大鼠少喝水，更盐水，但水维持和蔗糖保持大鼠之间的摄入没有差异。检测到舔瓣模式的差异，包括通过蔗糖保持的大鼠蔗糖的更多舔/爆发，即使在总摄入不差的情况下也是如此。这些数据提供了证据表明，通过完全饮用蔗糖或生理盐水，可以减少成年大鼠水摄入量。

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