...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced drug delivery reviews >Restenosis following implantation of bare metal coronary stents: pathophysiology and pathways involved in the vascular response to injury.
【24h】

Restenosis following implantation of bare metal coronary stents: pathophysiology and pathways involved in the vascular response to injury.

机译：植入裸金属冠状动脉支架后的再狭窄：血管对损伤的反应涉及的病理生理学和途径。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review summarizes the restenotic process that occurs after the implantation of bare metal coronary stents. The pathology of in-stent restenosis is distinct from that seen after balloon angioplasty and is characterized by neointimal proliferation and extracellular matrix deposition. The degree of neointimal proliferation is proportional to the amount of injury, the intensity of the inflammatory infiltrate and the association of stent struts with lipid-filled plaque. In-stent restenosis also appears to be associated with systemic markers of inflammation. Shear stress has an important influence on restenosis as does the presence and adhesiveness of vascular progenitor cells. Clinical predictors (e.g., artery size, stent length, diabetes, and gender) may affect the incidence of restenosis seen after stent placement. A number of catheter-based interventions have been used to treat in-stent restenosis. Although preliminary data suggest that the use of drug-eluting stents may be effective, only intracoronary radiation has shown consistent efficacy in randomized trials.
机译：这篇综述总结了植入裸金属冠状动脉支架后发生的再狭窄过程。支架内再狭窄的病理学与球囊血管成形术后不同，其特征在于新内膜增生和细胞外基质沉积。新内膜增生的程度与损伤的程度，炎性浸润的强度以及支架撑杆与脂质填充斑块的关系成正比。支架内再狭窄也似乎与炎症的全身性标志有关。剪切应力对再狭窄有重要影响，血管祖细胞的存在和粘附也是如此。临床预测指标（例如动脉大小，支架长度，糖尿病和性别）可能会影响支架置入后再狭窄的发生率。许多基于导管的干预措施已用于治疗支架内再狭窄。尽管初步数据表明使用药物洗脱支架可能是有效的，但只有冠状动脉内放射在随机试验中显示出一致的疗效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号