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首页> 外文期刊>Archives of dermatological research. >Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis.
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Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis.

机译：血清可溶性Tie1水平患者患者患者的临床意义。

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摘要

Tie1 is an endothelial cell-specific tyrosine kinase receptor, which maintains vascular integrity and regulates angiogenesis via modulating angiopoietin/Tie2 signaling. Since the altered angiogenesis is closely related to the developmental process of systemic sclerosis (SSc), we herein investigated the clinical significance of serum soluble Tie1 (sTie1) levels and the expression levels of Tie1 in dermal microvascular endothelial cells (DMECs) in patients with SSc. Although serum sTie1 levels were comparable among total SSc, diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and healthy controls, SSc patients with decreased serum sTie1 levels had significantly shorter disease duration than those with serum sTie1 levels not decreased. In SSc patients with disease duration of >6 years, the prevalence of clinical symptoms associated with proliferative vasculopathy, such as digital ulcers, scleroderma renal crisis, and elevated right ventricular systolic pressure, was significantly higher in patients with decreased serum sTie1 levels than in those with serum sTie1 levels not decreased. In immunohistochemistry, Tie1 expression was reduced in DMECs of SSc patients with disease duration of <3 years compared with those of healthy controls. Collectively, in SSc patients with short disease duration, decreased serum sTie1 levels may reflect the down-regulation of Tie1 in DMECs. The decrease in serum sTie1 levels may serve as a marker of proliferative vasculopathy in SSc with disease duration of >6 years.
机译：TiE1是一种内皮细胞特异性酪氨酸激酶受体，其通过调节血管发成素/ Tie2信号传导来保持血管完整性并调节血管生成。由于改变的血管生成与系统性硬化症（SSC）的发育过程密切相关，因此我们在SSC患者中研究了血清可溶性TIE1（STIE1）水平和TIE1在SSC患者患者中的TIE1的临床意义及其表达水平。虽然血清STIE1水平在总SSC中相当，但弥漫性皮肤SSC（DCSSC），有限的皮肤SSC（LCSSC）和健康对照，SSC患者血清STIE1水平降低显着较短的疾病持续时间比血清STIE1水平未降低的患者显着较短。在SSC患者患有疾病持续时间> 6年的患者中，与增殖血管病变相关的临床症状的患病率，例如数字溃疡，硬皮病肾危机和升高的右心室收缩压，患者血清血清1水平降低显着高于那些血清STIE1水平没有减少。在免疫组织化学中，与健康对照组相比，SSC患者的DMEC在SSC患者的DMEC中减少了TiE1表达。在SSC患者患有短疾病持续时间的患者中，血清STIE1水平降低可能反映TIE1在DMEC中的下调。血清STIE1水平的减少可以用作SSC中增殖血管病变的标志物，疾病持续时间> 6年。

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