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首页> 外文期刊>Archives of dermatological research. >Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis.
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Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis.

机译：系统性硬化患者血清可溶性Tie1水平的临床意义。

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摘要

Tie1 is an endothelial cell-specific tyrosine kinase receptor, which maintains vascular integrity and regulates angiogenesis via modulating angiopoietin/Tie2 signaling. Since the altered angiogenesis is closely related to the developmental process of systemic sclerosis (SSc), we herein investigated the clinical significance of serum soluble Tie1 (sTie1) levels and the expression levels of Tie1 in dermal microvascular endothelial cells (DMECs) in patients with SSc. Although serum sTie1 levels were comparable among total SSc, diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and healthy controls, SSc patients with decreased serum sTie1 levels had significantly shorter disease duration than those with serum sTie1 levels not decreased. In SSc patients with disease duration of >6 years, the prevalence of clinical symptoms associated with proliferative vasculopathy, such as digital ulcers, scleroderma renal crisis, and elevated right ventricular systolic pressure, was significantly higher in patients with decreased serum sTie1 levels than in those with serum sTie1 levels not decreased. In immunohistochemistry, Tie1 expression was reduced in DMECs of SSc patients with disease duration of <3 years compared with those of healthy controls. Collectively, in SSc patients with short disease duration, decreased serum sTie1 levels may reflect the down-regulation of Tie1 in DMECs. The decrease in serum sTie1 levels may serve as a marker of proliferative vasculopathy in SSc with disease duration of >6 years.
机译：Tie1是一种内皮细胞特异性酪氨酸激酶受体，通过调节血管生成素/ Tie2信号传导来维持血管完整性并调节血管生成。由于血管生成的改变与系统性硬化症（SSc）的发展过程密切相关，因此我们在本文中研究了SSc患者血清中可溶性Tie1（sTie1）水平和真皮微血管内皮细胞（DMECs）中Tie1表达水平的临床意义。 。尽管血清sTie1水平在总SSc，弥漫性皮肤SSc（dcSSc），有限的皮肤SSc（lcSSc）和健康对照中具有可比性，但血清sTie1水平降低的SSc患者的病程明显短于血清sTie1水平未降低的患者。在疾病持续时间> 6年的SSc患者中，与血清sTie1水平降低的患者相比，与增生性血管病相关的临床症状（如指尖溃疡，硬皮病肾病和右室收缩压升高）的患病率显着更高。血清sTie1水平未降低。在免疫组织化学中，与健康对照组相比，病程<3年的SSc患者的DMEC中Tie1表达降低。总体而言，在疾病持续时间短的SSc患者中，血清sTie1水平降低可能反映了DMEC中Tie1的下调。血清sTie1水平降低可能是SSc病程> 6年的增生性血管病的标志。

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