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首页> 外文期刊>Archives of dermatological research. >Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis.
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Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis.

机译：年轻人和老年健康人类的宁静水分损失：系统评价和荟萃分析。

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摘要

Transepidermal water loss (TEWL) is regarded as one of the most important parameters for characterizing skin barrier function but an agreed upon definition of what a "normal" TEWL is does not exist. In order to determine generalizable TEWL values for healthy adults, a systematic review and meta-analysis was conducted. The databases MEDLINE and EMBASE and publication lists were screened. After full-text appraisal of 398 studies, 231 studies were excluded due to unclear or insufficient reporting. 167 studies providing data about 50 skin areas were included in the final data synthesis. Pooled sample sizes ranged from n = 5 for the left cheek and the left lower back to a maximum of n = 2,838 for the right midvolar forearm area. The lowest TEWL of 2.3 (95 % CI 1.9-2.7) g/m(2)/h was calculated for the breast skin, the highest TEWL of 44.0 (39.8-48.2) g/m(2)/h for the axilla. TEWL in individuals being 65 years and above was consistently lower compared to the group of 18- to 64-year-old individuals. The quality of reporting TEWL in humans should be increased in future studies.
机译：TRANSEPIDERMAL水损失（TEWL）被认为是表征皮肤屏障功能的最重要参数之一，但是关于不存在“正常”TEWL的定义的商定。为了确定健康成年人的概括TEWL值，进行系统审查和荟萃分析。筛选数据库Medline和Embase和Publication Lists。在398项研究的全文评估后，由于报告不明确或不充分，将排除231项研究。 167项，提供约50个皮肤区域的研究包括在最终数据合成中。汇集的样品尺寸范围为左侧脸颊的n = 5，左下较大的右下方为右侧前臂区域的n = 2,838。为乳腺皮肤计算2.3（95％CI 1.9-2.7）G / M（2）/ h的最低TEWL，腋芽为44.0（39.8-48.2）g / m（2）/ h的最高TEWL。与18岁至64岁的人的团体相比，个人在65岁及以上的人中的TEWL始终如一。在未来的研究中应该增加人类中的报告TEWL的质量。

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