...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of Surgery >The Pattern of Residual Tumor After Neoadjuvant Chemotherapy for Locally Advanced Esophageal Cancer and Its Clinical Significance
【24h】

The Pattern of Residual Tumor After Neoadjuvant Chemotherapy for Locally Advanced Esophageal Cancer and Its Clinical Significance

机译：Neoadjuvant化疗后残留肿瘤的模式进行局部晚期食管癌及其临床意义

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: To investigate the residual pattern of esophageal cancer in the esophageal wall after neoadjuvant chemotherapy (NAC) and its clinical significance. Background: NAC is a standard treatment for locally advanced esophageal cancer; however, residual tumor patterns in resected specimens after NAC and their clinico-pathological characteristics remain unknown. Methods: One hundred twenty consecutive patients with cT3 or deeper esophageal cancer underwent curative esophagectomy after NAC and achieved grade 2 histological responses between 2000 and 2016. Hematoxylin-eosin staining of residual tumor sections revealed 4 remnant categories: Type 1: shallow, Type 2: central, Type 3: deep, and Type 4: diffuse. We examined associations between these Types and clinico-pathological factors, including prognosis. Results: Forty-five (38%) specimens had no residual tumor cells in the mucosal layer. The adventitia layer displayed the lowest residual tumor cell frequency (18%) among all layers. Types 1, 2, 3, and 4 residual tumor patterns were found in 49 (41%), 33 (28%), 9 (8%), and 29 (24%) patients, respectively. Type 4 showed the maximum standard uptake value after NAC; Types 3 and 4 had higher ratios of venous invasion than Type 1 or 2. Patients with Type 3 or 4 more frequently developed pleural dissemination or distant metastasis than patients with Type 1 or 2. Survival was similar among the 4 Types. Conclusions: After NAC for locally advanced esophageal cancer, the shallow residual tumor pattern was most common, but approximately 40% of specimens showed no tumor cells in the mucosal layer. Deep and diffuse remnant patterns were associated with high risks of pleural dissemination and distant metastasis.
机译：目的：在新辅助化疗（NAC）后食管壁上食管癌中食管癌的残留模式及其临床意义。背景：NAC是局部晚期食管癌的标准治疗;然而，NAC后切除标本的残留肿瘤模式及其临床病理特征仍然未知。方法：NAC后一百二十名连续患有CT3或更深的食管癌治疗食管癌的疗法食管切除术后2级和2016年的2级组织学反应。残留肿瘤切片的苏木精 - 曙红染色显示出4型遗留类别：1型：浅，2型：中央，3型：深，4型：漫反射。我们检查了这些类型和临床病理因素之间的关联，包括预后。结果：四十五（38％）标本在粘膜层中没有残留的肿瘤细胞。 Adventitia层在所有层中显示出最低的残留肿瘤细胞频率（18％）。在49（41％），33（28％），9（8％）和29名（24％）患者中发现了1,2,3和4种残留的肿瘤模式。 4型显示NAC后的最大标准摄取值; 3和4型比1或2型更高的静脉侵袭比率比1型或4型患者比1型或2型患者更频繁地发育的胸膜溶解或远处转移。生存在4种类型中类似。结论：在NAC进行局部晚期食管癌后，浅埋肿瘤模式最常见，但大约40％的标本在粘膜层中显示出肿瘤细胞。深度和漫反应模式与高风险的胸腔传播和远处转移相关。

著录项

  • 来源
    《Annals of Surgery》 |2020年第5期|共10页
  • 作者

    Hashimoto Tadayoshi; Makino Tomoki; Yamasaki Makoto; Tanaka Koji; Miyazaki Yasuhiro; Takahashi Tsuyoshi; Kurokawa Yukinori; Motoori Masaaki; Kimura Yutaka; Nakajima Kiyokazu; Morii Eiichi; Mori Masaki; Doki Yuichiro;

  • 作者单位

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Gen Med Ctr Dept Surg Osaka Japan;

    Kindai Univ Dept Surg Fac Med Osaka Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Pathol Suita Osaka Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

    Osaka Univ Grad Sch Med Dept Gastroenterol Surg 2-2-E2 Yamadaoka Suita Osaka 5650871 Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 外科学;
  • 关键词

    esophageal cancer; neoadjuvant chemotherapy; patterns of residual tumor; recurrence site;

    机译：食管癌;Neoadjuvant化疗;残留肿瘤的模式;复发遗址;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号