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Thermosensitive sol-gel reversible hydrogels.

机译：热敏溶胶-凝胶可逆水凝胶。

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摘要

Aqueous polymer solutions that are transformed into gels by changes in environmental conditions, such as temperature and pH, thus resulting in in situ hydrogel formation, have recently attracted the attention of many investigators for scientific interest and for practical biomedical or pharmaceutical applications. When the hydrogel is formed under physiological conditions and maintains its integrity for a desired period of time, the process may provide various advantages over conventional hydrogels. Because of the simplicity of pharmaceutical formulation by solution mixing, biocompatibility with biological systems, and convenient administration, the pharmaceutical and biomedical uses of the water-based sol-gel transition include solubilization of low-molecular-weight hydrophobic drugs, controlled release, labile biomacromolecule delivery, such as proteins and genes, cell immobilization, and tissue engineering. When the formed gel is proven to be biocompatible and biodegradable, producing non-toxic degradation products, it will provide further benefits for in vivo applications where degradation is desired. It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects. This review stresses the polymeric systems of natural or modified natural polymers, N-isopropylacrylamide copolymers, poly(ethylene oxide)/poly(propylene oxide) block copolymers, and poly(ethylene glycol)/poly(D,L-lactide-co-glycolide) block copolymers.
机译：由于诸如温度和pH等环境条件的变化而转变成凝胶的聚合物水溶液，从而导致原位水凝胶的形成，近来引起了许多研究者的关注，以引起科学兴趣以及实际的生物医学或药学应用。当水凝胶在生理条件下形成并在期望的时间段内保持其完整性时，与常规水凝胶相比，该方法可提供各种优点。由于通过溶液混合的药物制剂简单，与生物系统的生物相容性以及方便的给药，水基溶胶-凝胶转变的药物和生物医学用途包括低分子量疏水性药物的增溶，控制释放，不稳定的生物大分子传递，例如蛋白质和基因，细胞固定化和组织工程学。当所形成的凝胶被证明具有生物相容性和可生物降解性，并产生无毒的降解产物时，它将为需要降解的体内应用提供更多好处。总结一下经历溶胶-凝胶转变（尤其是由于温度）的聚合物体系是及时的，重点是潜在的转变机理和潜在的传递方面。这篇评论强调了天然或改性天然聚合物，N-异丙基丙烯酰胺共聚物，聚（环氧乙烷）/聚（环氧丙烷）嵌段共聚物和聚（乙二醇）/聚（D，L-丙交酯-乙交酯）的聚合物体系）嵌段共聚物。

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