...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced drug delivery reviews >Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery.
【24h】

Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery.

机译：细胞对机械化学微环境的反应-对再生医学和药物递送的影响。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Soft-tissue cells are surprisingly sensitive to the elasticity of their microenvironment, suggesting that traditional culture plastic and glass are less relevant to tissue regeneration and chemotherapeutics than might be achieved. Cells grown on gels that mimic the elasticity of tissue reveal a significant influence of matrix elasticity on adhesion, cytoskeletal organization, and even the differentiation of human adult derived stem cells. Cellular forces and feedback are keys to how cells feel their mechanical microenvironment, but detailed molecular mechanisms are still being elucidated. This review summarizes our initial findings for multipotent stem cells and also the elasticity-coupled effects of drugs on cancer cells and smooth muscle cells. The drugs include the contractility inhibitor blebbistatin, the proliferation inhibitor mitomycin C, an apoptotis-inducing antibody against CD47, and the translation inhibitor cycloheximide. The differential effects not only lend insight into mechano-sensing of the substrate by cells, but also have important implications for regeneration and molecular therapies.
机译：软组织细胞对它们的微环境的弹性出奇地敏感，这表明传统的培养塑料和玻璃与组织再生和化学疗法的相关性较弱。在模仿组织弹性的凝胶上生长的细胞揭示出基质弹性对粘附，细胞骨架组织甚至人类成年干细胞分化的重大影响。细胞力和反馈是细胞如何感受其机械微环境的关键，但是详细的分子机制仍在阐明中。这篇综述总结了我们对多能干细胞的初步发现，以及药物对癌细胞和平滑肌细胞的弹性耦合作用。这些药物包括收缩抑制剂blebbistatin，增殖抑制剂丝裂霉素C，针对CD47的凋亡诱导抗体和翻译抑制剂环己酰亚胺。差异作用不仅有助于了解细胞对底物的机械感测，而且对再生和分子疗法也具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号