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首页> 外文期刊>Advanced drug delivery reviews >Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.

机译：化妆品和皮肤病学制剂中的固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）。

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Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990 s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages-also potential limitations-of SLN for the use in topical cosmetic and pharmaceutical formulations. Features discussed include stabilisation of incorporated compounds, controlled release, occlusivity, film formation on skin including in vivo effects on the skin. As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented, the structural specialties described and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations. For both SLN and NLC, the technologies to produce the final topical formulation are described, especially the production of highly concentrated lipid nanoparticle dispersions >30-80% lipid content. Production issues also include clinical batch production, large scale production and regulatory aspects (e. g. status of excipients or proof of physical stability).
机译：固态脂质纳米颗粒（SLN）于1990年代初开发，作为乳液，脂质体和聚合物纳米颗粒的替代载体系统。本文回顾了局部用化妆品和药物制剂中SLN的优点-以及潜在的局限性。讨论的特征包括掺入的化合物的稳定，控制释放，闭塞性，在皮肤上形成膜，包括对皮肤的体内作用。作为具有固体基质的新型脂质纳米颗粒，提出了纳米结构脂质载体（NLC），描述了结构特点并讨论了改进方法，例如，增加负载能力，物理和化学长期稳定性，触发释放以及潜在的过饱和局部用药。对于SLN和NLC，均描述了制备最终局部用制剂的技术，尤其是脂质含量> 30-80％的高浓度脂质纳米颗粒分散体的生产。生产问题还包括临床批量生产，大规模生产和监管方面（例如，赋形剂的状态或物理稳定性的证明）。

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