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首页> 外文期刊>Archives of pharmacal research >Protective effects of 6,7,4′-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells
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Protective effects of 6,7,4′-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells

机译：6,7,4'-trihydroxyisoflavone，Daidzein的主要代谢物，在SH-Sy5Y人神经母细胞瘤细胞中的6-羟基多胺诱导的神经细胞死亡中的抗保护作用

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摘要

Daidzein, one of the important isoflavones, is extensively metabolized in the human body following consumption. In particular, 6,7,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, has been the focus of recent investigations due to its various health benefits, such as anti-cancer and anti-obesity effects. However, the protective effects of 6,7,4′-THIF have not yet been studied in models of Parkinson’s disease (PD). Therefore, the present study aimed to investigate the protective activity of 6,7,4′-THIF on 6-hydroxydopamine (OHDA)-induced neurotoxicity in SH-SY5Y human neuroblastoma cells. Pretreatment of SH-SY5Y cells with 6,7,4′-THIF significantly inhibited 6-OHDA-induced neuronal cell death, lactate dehydrogenase release, and reactive oxygen species production. In addition, 6,7,4′-THIF significantly attenuated reductions in 6-OHDA-induced superoxide dismutase activity and glutathione content. Moreover, 6,7,4′-THIF attenuated alterations in Bax and Bcl-2 expression and caspase-3 activity in 6-OHDA-induced SH-SY5Y cells. Furthermore, 6,7,4′-THIF significantly reduced 6-OHDA-induced phosphorylation of c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and extracellular signal-regulated kinase 1/2. Additionally, 6,7,4′-THIF effectively prevented 6-OHDA-induced loss of tyrosine hydroxylase. Taken together, these results suggest that 6,7,4′-THIF, a major metabolite of daidzein, may be an attractive option for treating and/or preventing neurodegenerative disorders such as PD.
机译：Daidzein是一个重要的异黄酮之一，在消费后在人体中广泛代谢。特别是，6,7,4,4'-trihydroxyisoflavone（Thif）是Daidzein的主要代谢物，由于其各种健康益处，例如抗癌和抗肥胖效应。然而，尚未在帕金森病（PD）的模型中尚未研究6,7,4'-THIF的保护作用。因此，本研究旨在研究6,7,4'-THIF对6-羟基多胺（OHDA）的保护活性 - 诱导SH-SY5Y人神经母细胞瘤细胞的神经毒性。具有6,7,4'-ThIF的SH-SY5Y细胞的预处理显着抑制了6- OHDA诱导的神经元细胞死亡，乳酸脱氢酶释放和反应性氧物种生产。此外，6,7,4''-THIF在6-OHDA诱导的超氧化物歧化酶活性和谷胱甘肽含量显着减弱。此外，在6-OHDA诱导的SH-SY5Y细胞中，6,7,4'-THIF在BAX和BCL-2表达和Caspase-3活性中的变化和Caspase-3活性。此外，6,7,4'-THIF显着降低了6-OHDA诱导的C-JUM N-末端激酶，P38丝裂原活化蛋白激酶和细胞外信号调节激酶1/2的磷酸化。另外，6,7,4'-THIF有效地防止了6-OHDA诱导的酪氨酸羟化酶的丧失。总之，这些结果表明，6,7,4''-THIF，Daidzein的主要代谢物，可能是治疗和/或预防诸如Pd等神经变性疾病的有吸引力的选择。

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  • 来源
    《Archives of pharmacal research》 |2019年第12期|共11页
  • 作者

    Yong-Hyun Ko; Seung-Hwan Kwon; Seon-Kyung Kim; Bo-Ram Lee; Kwang-Hyun Hur; Young-Jung Kim; Seong-Eon Kim; Seok-Yong Lee; Choon-Gon Jang;

  • 作者单位

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

    1grid.264381.a0000 0001 2181 989XDepartment of Pharmacology School of PharmacySungkyunkwan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    6; 7; 4′-Trihydroxyisoflavone; 6-Hydroxydopamine; Oxidative stress; Apoptosis; Parkinson’s disease;

    机译：6;7;4'-三羟基辛异黄酮;6-羟基多戊胺;氧化应激;凋亡;帕金森病;

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