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首页> 外文期刊>Archives of Oral Biology >Probiotics: A non-conventional therapy for oral lichen planus
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Probiotics: A non-conventional therapy for oral lichen planus

机译：益生菌：口服地衣直升机的非常规治疗

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摘要

Oral lichen planus (OLP) is a common T-cell mediated chronic inflammatory disease. Although the etiology is still unclear, present studies suggest that the composition of the oral microbiota and psychological problems are implicated in the etiology of OLP. The pathogenesis of OLP includes mainly antigen-specific and non-specific mechanisms. Antigen-specific mechanisms involve T-cell activation following antigen presentation and apoptosis of basal keratinocytes triggered by CD8(+) cytotoxic T cells, while non-specific mechanisms consist of matrix metalloproteinase over-expression and mast cell degranulation in OLP lesions. Therapies for OLP are mainly used to control symptoms and a specific cure is not yet available. Probiotics are capable of modulating the immune response in a strain-specific manner. They are able to alleviate microbial infection and suppress T cell activation, infiltration and proliferation, as well as suppress keratinocyte apoptosis and nuclear factor-kappa B signaling. Furthermore, probiotics can also modulate the production of inflammatory cytokines and microRNAs, inhibit MMP-9 expression and mast cell degranulation, and ameliorate psychological problems, all of which are involved in the pathogenesis of OLP. Therefore, we hypothesize that probiotics may be applicable to OLP as a safe, inexpensive and non-conventional therapy.
机译：口服地衣直升机（OLP）是一种常见的T细胞介导的慢性炎症疾病。虽然病因尚不清楚，但目前的研究表明，口腔微生物群和心理问题的组成涉及OLP的病因。 OLP的发病机制主要包括抗原特异性和非特异性机制。抗原特异性机制涉及在CD8（+）细胞毒性T细胞引发的抗原呈递和基础角蛋白细胞的基础角蛋白细胞凋亡之后的T细胞活化，而非特异性机制由基质金属蛋白酶过表达和肥大细胞中的OLP病变中脱溶。 OLP的疗法主要用于控制症状，并且尚未使用特定的固化。益生菌能够以菌株特异性方式调节免疫应答。它们能够缓解微生物感染并抑制T细胞活化，渗透和增殖，以及抑制角质形成细胞凋亡和核因子-Kappa发信息。此外，益生菌还可以调节炎性细胞因子和微润荷的产生，抑制MMP-9表达和肥大细胞脱粒，以及改善心理问题，所有这些都参与OLP的发病机制。因此，我们假设益生菌可能适用于OLP作为安全，廉价和非常规治疗。

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  • 来源
    《Archives of Oral Biology》 |2017年第2017期|共7页
  • 作者

    Han Xiao; Zhang Jing; Tan Yaqin; Zhou Gang;

  • 作者单位

    Wuhan Univ Sch &

    Hosp Stomatol State Key Lab Breeding Base Basic Sci Stomatol Hu Wuhan Hubei;

    Wuhan Univ Sch &

    Hosp Stomatol State Key Lab Breeding Base Basic Sci Stomatol Hu Wuhan Hubei;

    Wuhan Univ Sch &

    Hosp Stomatol State Key Lab Breeding Base Basic Sci Stomatol Hu Wuhan Hubei;

    Wuhan Univ Sch &

    Hosp Stomatol State Key Lab Breeding Base Basic Sci Stomatol Hu Wuhan Hubei;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    Probiotics; Oral lichen planus; Treatment;

    机译：益生菌;口服地衣直升机;治疗;

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