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首页> 外文期刊>Archives of Oral Biology >Recovery after PILP remineralization of dentin lesions created with two cariogenic acids
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Recovery after PILP remineralization of dentin lesions created with two cariogenic acids

机译：用两种致癌酸产生的牙本质病变的牙本质病变后恢复

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Highlights ? Acetate and lactate made different residual dentin structures in artificial lesions. ? PILP process recovered both structure and mechanical properties for both lesions. ? Incorporating PILP into CaP buffer significantly improved remineralization of artificial dentin lesion. Abstract Objectives Acetate and lactate are important cariogenic acids produced by oral bacteria. They produced different residual dentin structures in artificial lesions of similar depth. We evaluated if such lesions responded in the same way to a polymer-induced-liquid-precursor (PILP) remineralization. Design Dentin blocks obtained from human third molars, divided into 6 groups (n = 3). Blocks were demineralized with acetate (66 h) or lactate (168 h) buffer at pH 5.0 to create 140 μm target lesion depths. A-DEM and L-DEM groups received no remineralization. Other groups were remineralized for 14 days. 100 μg/mL polyaspartate was added into the remineralizing buffer for A-PIL and L-PIL, whereas A-CAP and L-CAP were treated with the same solution but without polyaspartate. Cross-sectioned blocks were examined for shrinkage and AFM-topography. Line profiles of reduced elastic modulus (E r ) were obtained by AFM-based nanoindentation across the lesion. Ultrastructures were examined with TEM. Results A-PIL and L-PIL recovered in shrinkage to the original height of the dentin and it appeared normal with tubules, with increases in E r at both outer flat and inner sloped zones. At the sloped zone, acetate lesions lost more E r but recovery rate after PILP was not statistically different from lactate lesions. A-CAP and L-CAP showed surface precipitates, significantly less recovery in shrinkage or E r as compared to PILP groups. TEM-ultrastructure of PILP groups showed similar structural and mineral components in the sloped zone for lesions produced by either acid. Conclusions The PILP process provided significant recovery of both structure and mechanical properties for artificial lesions produced with acetate or lactate.
机译：强调 ？醋酸盐和乳酸在人造病变中制造了不同的残留牙本质结构。还PilP过程回收了两个病变的结构和机械性能。还将PilP掺入帽缓冲液显着改善了人造牙本质病变的再矿化。摘要目标醋酸盐和乳酸是口腔细菌产生的重要致癌酸。它们在类似深度的人工病变中产生了不同的残留牙本质结构。如果这种病变以与聚合物诱导的液体 - 前体（PLP）再矿化相同的方式评估。从人第三臼齿获得的设计牙本质嵌段，分为6组（n = 3）。嵌段用醋酸盐（66小时）或乳酸（168小时）缓冲液在pH 5.0下脱矿物，以产生140μm的靶病变深度。 A-DEM和L-DEM组没有遗产。其他群体再归化14天。将100μg/ ml的聚菠天加入到α-p1和L-pil的再矿化缓冲液中，而用相同的溶液处理盖子和L-帽，但没有聚菠天醇。检查横截面块进行收缩和AFM形貌。通过基于AFM的纳米凸缘在病变中获得降低的弹性模量（E R）的线轮廓。用TEM检查超微结构。结果A-Pil和L-LIP在牙本质的原始高度中回收，并用小管出现正常，在外平坦和内倾斜的区域的E R增加。在倾斜区，醋酸盐病变失去了更多的E R但PilP在与乳酸病变不同的情况下恢复速率。与Pilp组相比，A帽和L帽显示表面沉淀物，显着较低，收缩率或E r的恢复明显较小。 PilP组的TEM超微结构在​​倾斜区显示出类似的结构和矿物成分，用于由任一酸产生的病变。结论PilP工艺提供了用醋酸盐或乳酸的人工病变的结构和机械性能的显着恢复。

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