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首页> 外文期刊>Acta Veterinaria Brno >Use of carazolol at pre-synchronized timed artificial insemination in cows.
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Use of carazolol at pre-synchronized timed artificial insemination in cows.

机译：在牛的预同步定时人工授精中使用咔唑。

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Efficacy of the beta -adrenergic receptor blocker (carazolol) at Timed Artificial Insemination (TAI) was investigated. Cows (n=73) were pre-synchronized with two PGF2 alpha injections given 14 d apart to initiate the Ovsynch protocol at early and middle luteal stages 14 d later, and received injections of GnRH and PGF2 alpha seven d apart followed by GnRH 48 h later, and TAI 16-18 h later. Corpus luteum (CL) was detected via rectal palpation at the beginning of the Ovsynch protocol. Carazolol (Treatment I; n=41) or physiologic saline (Treatment II; n=32) were administered via jugular vein five min before TAI. Uterine tone was determined prior to infusion and at TAI via rectal palpation. Pregnancies were diagnosed with transrectal ultrasonography 40+or-7 d after TAI. Uterine tone was 2.8 (1.4-5.3) times higher (P<0.01) in Treatment I than that in Treatment II at TAI. Increase in uterine tone was affected by treatment x CL x parity (P<0.05), and 66.7%, 75%, 52.6%, 100% and 16.7%, 33.3%, 25%, 28.6% in primiparous cows with CL and without CL, and in multiparous cows with CL and without CL in Treatments I and II, respectively. Pregnancy rates did not differ between treatments I (34.2%) and II (40.6%). In conclusion, no beneficial effect of carazolol administration prior to TAI was found except for the increased uterine tone.
机译：研究了β-肾上腺素受体阻滞剂（carazolol）在定时人工授精（TAI）时的功效。将母牛（n = 73）与间隔14 d的两次PGF2 alpha注射进行预同步，以在14 d之后的黄体早期和中期启动Ovsynch方案，并在间隔7 d接受GnRH和PGF2 alpha的注射，然后进行GnRH 48 h之后，TAI 16-18小时后。在Ovsynch协议开始时通过直肠触诊检测到黄体（CL）。在TAI前五分钟，通过颈静脉注射Carazolol（治疗I; n = 41）或生理盐水（治疗II; n = 32）。在输注之前和在TAI时通过直肠触诊确定子宫张力。 TAI后40或7 d经直肠超声检查诊断为妊娠。在TAI，治疗I的子宫色调比治疗II高2.8（1.4-5.3）倍（P <0.01）。有CL和无CL的初产奶牛的子宫口气增加受到治疗×CL×胎次的影响（P <0.05），分别为66.7％，75％，52.6％，100％和16.7％，33.3％，25％，28.6％。 ，以及分别在治疗I和治疗II中有CL和无CL的多胎牛中。在治疗I（34.2％）和治疗II（40.6％）之间，妊娠率没有差异。总之，除子宫张力增加外，未发现在TAI之前服用carazolol的有益作用。

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