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首页> 外文期刊>Archives of Toxicology >Novel treatment opportunities for sulfur mustard-related cancers: genetic and epigenetic perspectives
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Novel treatment opportunities for sulfur mustard-related cancers: genetic and epigenetic perspectives

机译：硫磺芥末相关癌症的新型治疗机会：遗传和表观遗传观点

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摘要

Sulfur mustard (SM), also known as mustard gas, is a chemical weapon which by now has been used in many wars. The most concerning SM toxic effect is probable carcinogenicity. In this study, the genetic and epigenetic mechanisms of SM carcinogenicity, by focusing on treatment of SM-associated malignancies, particularly gene therapeutics, cancer vaccines, and epigenetic medications, have been criticized. The required data were collected through an organized search on valid scientific databases. For SM carcinogenicity due to acute or chronic exposure, the entire original and review articles were evaluated. In addition, studies on the therapeutic effects of available genetic and epigenetic medications were included. Currently, four gene therapeutics, two cancer vaccines with genetic bases, and seven epigenetic medications are available for cancer treatment. Genetic and epigenetic cancer treatments including Gendicine, Imlygic, Provenge, Cimavax-EGF, Azacitidine, Vorinostat, Romidepsin, and Belinostat will yield outstanding benefits for SM-exposed patients who suffer from cancer.
机译：硫磺芥末（SM），也称为芥末煤气，是一种化学武器，即现在已经使用过许多战争。最有关的SM毒性效应是可能的致癌性。在这项研究中，通过专注于治疗SM相关的恶性肿瘤，特别是基因治疗剂，癌症疫苗和表观遗传药物的SM致癌性的遗传和表观遗传机制受到批评。通过有关有效科学数据库的有组织的搜索来收集所需的数据。对于由于急性或慢性暴露而导致的SM致癌性，评估整个原始和审查制品。此外，还包括有关可用遗传和表观遗传药物治疗效果的研究。目前，四种基因治疗剂，两种癌症疫苗和七种表观遗传药物可用于癌症治疗。遗传性和表观遗传癌症治疗包括官僚，泛素，探矿，Cimavax-EGF，氮酸辛胺，vorinostat，Romidepsin和Belinostat将为患有癌症的SM暴露患者产生突出的益处。

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