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The current role of thiazolidinediones in diabetes management

机译：噻唑烷二酮在糖尿病管理中的目前作用

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摘要

Among the epidemics of modern time, type 2 diabetes mellitus (T2DM) is one of the main contributors to overall morbidity as well as mortality. A number of different treatment options are available for the management of diabetes. Among them thiazolidinediones (TZDs) is an interesting drug class since it does not target the result of T2DM, i.e., hyperglycemia but rather some of the core mechanisms of the disease. Indeed, glitazones increase insulin sensitivity by activating the peroxisome proliferator-activated receptor gamma, which plays an important role in regulating various metabolic parameters. Although TZDs have an established efficacy in T2DM treatment, their usage during the past years was questioned following the emergence of some alarming data regarding their safety and especially the cardiovascular safety of rosiglitazone. As a result, there is often some skepticism about the current role of TZDs in T2DM management. This mainly affects rosiglitazone even leading to its withdrawal from several markets in contrast to pioglitazone, which has shown a beneficial cardiovascular profile. A comprehensive assessment of the benefit-to-risk ratio of TZDs is required in order to better understand the place of these drugs in T2DM management.
机译：在现代时间的流行病中，2型糖尿病（T2DM）是整体发病率的主要贡献之一以及死亡率。糖尿病的管理可以使用许多不同的治疗方案。其中噻唑烷二酮（TZDS）是一种有趣的药物类，因为它不靶向T2DM的结果，即高血糖，而是疾病的一些核心机制。实际上，Gliitazones通过激活过氧化物体增殖物激活的受体γ来增加胰岛素敏感性，这在调节各种代谢参数方面发挥着重要作用。虽然TZDS在T2DM治疗中具有既定效率，但在过去几年中的使用情况在出现了关于其安全性的一些令人担忧的数据，特别是Rosiglitazone的心血管安全性之后受到质疑。因此，关于TZDS在T2DM管理中的当前作用通常存在一些怀疑论。这主要影响Rosiglitazone甚至导致其与Pioglitazone相反的几个市场的退出，这显示了有益的心血管概况。为了更好地理解这些药物在T2DM管理中，需要全面评估TZDS的福利风险比。

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