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首页> 外文期刊>ASAIO journal >Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model
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Individualized Biventricular Epicardial Augmentation Technology in a Drug-Induced Porcine Failing Heart Model

机译：毒性猪失败心脏模型中的个体化的五圈外膜增强技术

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摘要

For treatment of advanced heart failure, current strategies include cardiac transplantation or blood-contacting pump technology associated with complications, including stroke and bleeding. This study investigated an individualized biventricular epicardial augmentation technology in a drug-induced porcine failing heart model. A total of 11 pigs were used, for the assessment of hemodynamics and cardiac function under various conditions of support pressures and support durations (n = 4), to assess device positioning and function by in vivo computer tomographic imaging (n = 3) and to investigate a minimally invasive implantation on the beating heart (n = 4). Support pressures of 20-80 mmHg gradually augmented cardiac function parameters in this animal model as indicated by increased left ventricular stroke volume, end-systolic pressures, and decreased end-diastolic pressures. Strong evidence was found regarding the necessity of mechanical synchronization of support end with the isovolumetric relaxation phase of the heart. In addition, the customized, self-expandable implant enabled a marker-guided minimally invasive implantation through a 4cm skin incision using fluoroscopy. Correct positioning was confirmed in computer tomographic images. Continued long-term survival investigations will deliver preclinical evidence for further development of this concept.
机译：对于治疗先进的心力衰竭，目前的策略包括与并发症相关的心脏移植或血液接触泵技术，包括中风和出血。本研究研究了一种毒性猪失败的心脏模型中的个体化的前心外膜增强技术。使用总共11只猪，用于在各种支撑压力条件下评估血流动力学和心脏功能（n = 4），以评估装置定位和通过体内计算机断层成像（n = 3）和功能探讨在跳动心脏上的微创植入（n = 4）。通过增加左心室中风体积，末端 - 收缩压和最终 - 舒张压降低表示，在该动物模型中逐渐增强的心功能参数逐渐增强心功能参数。发现有关支撑件的机械同步的必要性与心脏的内含性松弛阶段的必要性。此外，定制的自扩张植入物能够通过使用荧光检查通过4cm皮肤切口进行标记引导的微创植入。在计算机断层图像中确认了正确定位。持续的长期生存调查将为这一概念的进一步发展提供突出的证据。

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