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首页> 外文期刊>Arthritis and Rheumatism >Association of Hippocampal Atrophy With Cerebrospinal Fluid Antibodies Against the NR2 Subtype of the Af-Methyl-D-Aspartate Receptor in Patients With Systemic Lupus Erythematosus and Patients With Primary Sjogren's Syndrome
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Association of Hippocampal Atrophy With Cerebrospinal Fluid Antibodies Against the NR2 Subtype of the Af-Methyl-D-Aspartate Receptor in Patients With Systemic Lupus Erythematosus and Patients With Primary Sjogren's Syndrome

机译：脑脊液抗体对系统性红斑狼疮患者的NR2亚型对脑脊液抗体的缔合脑萎缩与患者的NR2亚型。

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Objective. Cognitive dysfunction is common in both systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (SS). Antibodies against the NR2 subtype of the iV-methyl-D-aspartate receptor (anti-NR2 antibodies) cause hippocampal atrophy and cognitive impairment in mice and have been associated with memory impairment in both patients with SLE and patients with primary SS. In addition, a reduced volume of hippocampal gray matter has been demonstrated in both SLE and primary SS. This study was undertaken to investigate whether there is a connection between the presence of anti-NR2 antibodies and hippocampal atrophy in human diseases. Methods. Fifty patients with SLE and 50 patients with primary SS underwent clinical examination and cerebral magnetic resonance imaging. Anti-NR2 antibodies in cerebrospinal fluid (CSF) were measured, and hippocampal gray matter volumes were compared between patients who were positive for and those who were negative for anti-NR2 antibodies. Results. Patients with anti-NR2 antibodies in CSF had less hippocampal gray matter than patients without these antibodies. No other differences regarding gray matter volumes in other parts of the brain were identified. Conclusion. The present findings indicate that anti-NR2 antibodies in patients with SLE and primary SS cause neuronal death manifested as reduced hippocampal gray matter, as has been previously demonstrated in mice with autoimmune disease.
机译：客观的。在全身狼疮红斑（SLE）和原发性Sjogren综合征（SS）中，认知功能障碍是常见的。针对IV-甲基-D-天冬氨酸受体（抗NR2抗体）的NR2亚型的抗体导致小鼠的海马萎缩和认知障碍，并且与SLE和初级SS患者的患者中的记忆障碍有关。此外，在SLE和初级SS中已经证明了减少的海马灰质体积。本研究进行了调查是否存在抗NR2抗体和人类疾病中海马萎缩之间的联系。方法。 50例SLE和50例初级SS患者接受临床检查和脑磁共振成像。测量脑脊液（CSF）中的抗NR2抗体，比较了对阳性阳性的患者的海马灰质体积，以及抗NR2抗体的阴性的患者。结果。在CSF中抗NR2抗体的患者比没有这些抗体的患者具有较少的海马灰质。鉴定了对大脑其他地区的灰质体积的其他差异。结论。本研究结果表明，SLE和初级SS患者的抗NR2抗体导致神经元死亡表现为降低的海马灰质，如前所述，如前所述，在具有自身免疫性疾病的小鼠中。

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