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首页> 外文期刊>Arthritis and Rheumatism >Comparison of Outcomes in Adults With Pediatric-Onset Morphea and Those With Adult-Onset Morphea
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Comparison of Outcomes in Adults With Pediatric-Onset Morphea and Those With Adult-Onset Morphea

机译：具有儿科发病的成年人的结果比较和成人发作的情况

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Objective. Few studies have examined outcomes in adults with pediatric-onset morphea. The objective of the present study was to compare clinical outcomes and health-related quality of life (HRQOL) in adults with onset of morphea in childhood to those in patients with adult onset of morphea. Methods. Participants in the study were drawn from the Morphea in Adults and Children cohort and included 68 adults with pediatric-onset morphea and 234 patients with adult-onset morphea. Outcome measures included the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), physical examination findings, and HRQOL questionnaires. Results. Adults with pediatric-onset morphea were younger, had longer disease duration, and were more likely to have the linear subtype of morphea. Patients with pediatric-onset disease were less likely to have active disease. Among patients with active disease, those with pediatric-onset morphea had less disease activity as measured by the LoSCAT. Patients with pediatric-onset disease had higher severity of disease damage when measured by the physician's global assessment of damage, but had similar levels of disease damage when measured by the Localized Scleroderma Skin Damage Index. Patients with pediatric-onset disease had more favorable HRQOL scores for all measures, all of which were statistically significantly different from those in patients with adult-onset morphea.Conclusion. Adults with pediatric-onset morphea differ from patients with adult-onset disease with respect to disease subtype, severity of disease activity and damage, and levels of HRQOL.
机译：客观的。少数研究在具有儿科发病的情况下检查了成年人的结果。本研究的目的是将童年中病人发病的成人发病与成人发病患者的临床成果和健康有关的生命质量（HRQOL）进行比较。方法。该研究中的参与者来自成人和儿童队列的语素中，并包含68名成人与儿科发作的Morphea和234例成人发作的Morphea患者。结果措施包括本地化的硬皮病皮肤评估工具（Loscat），体检结果和HRQOL问卷。结果。具有儿科发病Morphea的成年人患者较年轻，疾病持续时间较长，并且更有可能具有Morphea的线性亚型。患有儿科发病疾病的患者不太可能有活跃的疾病。在有活性疾病的患者中，患有儿科发作的Morphea的患者患有效果较少的疾病活动。儿科发病疾病的患者在医生的全球损害评估时造成的疾病损伤程度较高，但在通过本地化的硬皮病皮肤损伤指数测量时具有相似的疾病损伤水平。患有儿科发病疾病的患者对所有措施的HRQOL分数更有利，所有这些措施都与成人发作的Morphea的患者有统计学显着不同。结论。具有儿科发病的成年人与成人发作疾病的患者不同于疾病亚型，疾病活动严重程度和损伤以及HRQOL水平的患者。

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