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首页> 外文期刊>Arthritis & rheumatology. >Comparison of Outcomes in Adults With Pediatric-Onset Morphea and Those With Adult-Onset Morphea A Cross-Sectional Study From the Morphea in Adults and Children Cohort
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Comparison of Outcomes in Adults With Pediatric-Onset Morphea and Those With Adult-Onset Morphea A Cross-Sectional Study From the Morphea in Adults and Children Cohort

机译：成人和儿童成年睡眠的结果比较–来自成人和儿童队列中的睡眠研究的横断面研究

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Objective. Few studies have examined outcomes in adults with pediatric-onset morphea. The objective of the present study was to compare clinical outcomes and health-related quality of life (HRQOL) in adults with onset of morphea in childhood to those in patients with adult onset of morphea. Methods. Participants in the study were drawn from the Morphea in Adults and Children cohort and included 68 adults with pediatric-onset morphea and 234 patients with adult-onset morphea. Outcome measures included the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), physical examination findings, and HRQOL questionnaires. Results. Adults with pediatric-onset morphea were younger, had longer disease duration, and were more likely to have the linear subtype of morphea. Patients with pediatric-onset disease were less likely to have active disease. Among patients with active disease, those with pediatric-onset morphea had less disease activity as measured by the LoSCAT. Patients with pediatric-onset disease had higher severity of disease damage when measured by the physician's global assessment of damage, but had similar levels of disease damage when measured by the Localized Scleroderma Skin Damage Index. Patients with pediatric-onset disease had more favorable HRQOL scores for all measures, all of which were statistically significantly different from those in patients with adult-onset morphea. Conclusion. Adults with pediatric-onset morphea differ from patients with adult-onset disease with respect to disease subtype, severity of disease activity and damage, and levels of HRQOL.
机译：目的。很少有研究检查成人小儿吗啡形态的结局。本研究的目的是比较儿童期成人和成人期吗啡的临床结果和健康相关生活质量（HRQOL）。方法。该研究的参与者来自成年和儿童队列中的Morphea，包括68名成年儿型吗啡成人和234名成年儿型吗啡患者。结果措施包括本地化硬皮皮肤评估工具（LoSCAT），体格检查结果和HRQOL问卷。结果。患儿小儿吗啡的成年人更年轻，病程更长，并且更容易患有吗啡的线性亚型。患儿病的患者较少发生活动性疾病。根据LoSCAT的测量，在活动性疾病患者中，小儿发作性吗啡患者的疾病活动较少。当通过医生的整体损害评估来衡量时，患儿病的患者具有更高的疾病损害严重程度，但是通过局部硬皮病皮肤损害指数来衡量，则具有相似水平的疾病损害。小儿发作性疾病患者的所有指标均具有更有利的HRQOL评分，所有这些统计学上均与成年性吗啡患者的HRQOL评分有显着差异。结论。在儿童亚型，疾病活动和损害的严重程度以及HRQOL水平方面，患有小儿吗啡形态的成人与患有成人疾病的患者有所不同。

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