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首页> 外文期刊>Asia Pacific journal of clinical nutrition >Association between serum ferritin and non-alcoholic fatty liver disease among middle-aged and elderly Chinese with normal weight
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Association between serum ferritin and non-alcoholic fatty liver disease among middle-aged and elderly Chinese with normal weight

机译：血清叶状素与非酒精性脂肪肝疾病之间的关系，中老年人的重量

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Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) in normal-weight population is becoming an important health issue. This study aimed to assess the association between serum ferritin (SF) and NAFLD among middle-aged and elderly Chinese with normal weight. Methods and Study Design: A total of 2029 Chinese adults aged 35-70 years with normal weight were involved in this cross-sectional study. General information, lifestyle factors and laboratory characteristics were collected. The concentrations of serum alanine aminotransferase (ALT) and SF were recorded. Receiver operating characteristic (ROC) was applied to assess predictive performance of SF for NAFLD. Logistic regression analysis was conducted to evaluate the associations of SF with NAFLD and elevated ALT. Results: Compared with controls, subjects with NAFLD had higher SF concentrations (p<0.001). In multivariate logistic regression analyses, the odds ratios (ORs) with 95% confidence intervals (CIs) of NAFLD were 3.19 (2.07-4.92) for the highest versus lowest quartile of SF. ROC analysis revealed a predictive ability of SF for NAFLD with an area under the curve of 0.660 (95% CI, 0.63-0.69). In addition, higher SF was significantly associated with increased risk of elevated ALT (OR=1.84, 95% CI: 1.32-2.55). In stratified analyses by gender and age, the positive associations of SF with the risk of NAFLD and elevated ALT were only observed in women and 35 similar to 49y group. Conclusions: SF was positively associated with the risk of NAFLD and elevated ALT among normal-weight Chinese adults. ROC analysis suggested that SF may serve as an indicator of predicting NAFLD.
机译：背景和目标：正常重量人口中的非酒精脂肪肝病（NAFLD）正在成为一个重要的健康问题。本研究旨在评估中年和老年人的血清铁蛋白（SF）和NAFLD之间的关联，具有正常体重。方法和研究设计：在这一横断面研究中，共有2029名患有35-70岁的中国成人，涉及正常体重。收集一般信息，生活方式因素和实验室特征。记录血清丙氨酸氨基转移酶（ALT）和SF的浓度。采用接收器操作特征（ROC）来评估NAFLD的SF的预测性能。进行逻辑回归分析，以评估SF与NAFLD和高架升高的关联。结果：与对照相比，NAFLD的受试者具有更高的SF浓度（P <0.001）。在多变量逻辑回归分析中，NAFLD的95％置信区间（CIS）的差距（或）为3.19（2.07-4.92），最高与SF最低四分位数。 ROC分析揭示了NAFLD的预测能力，曲线下的区域为0.660（95％CI，0.63-0.69）。此外，较高的SF与升高的ALT的风险增加显着相关（或= 1.84,95％CI：1.32-2.55）。在性别和年龄的分层分析中，SF与NAFLD风险的阳性关联仅在妇女和35人中观察到49Y组。结论：SF与NAFLD的风险呈正常相关，普通大量中国成人中的ALT升高。 ROC分析表明，SF可以作为预测NAFLD的指标。

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