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Impact of cannula size and line length on venous line pressure in pediatric VA‐/VV‐ECLS circuits

机译:套管尺寸和线宽对小儿VA / VV-ECLS电路静脉线压力的影响

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Abstract The objective of this study was to do an in vitro evaluation of venous line pressure using different venous line lengths and venous cannula sizes in pediatric venoarterial extracorporeal life support (VA‐ECLS) and venovenous ECLS (VV‐ECLS) circuits. The pediatric VA‐ECLS circuit consisted of a Xenios i‐cor diagonal pump, a Maquet Quadrox‐i pediatric oxygenator, a Medtronic Biomedicus arterial cannula, a Biomedicus venous cannula, and 1/4″ ID arterial and venous tubing. The pediatric VV‐ECLS circuit was similar, except it included a Maquet Avalon ELITE bi‐caval dual lumen cannula. Circuits were primed with lactated Ringer’s solution and packed red blood cells (hematocrit 40%). Trials were conducted at various flow rates (VA‐ECLS: 250–1250?mL/min, VV‐ECLS: 250–2000?mL/min) using different venous tubing lengths (2, 4, and 6 feet) and cannula sizes (VA‐ECLS: A8Fr/V10Fr, A10Fr/V12Fr and A12Fr/V14Fr, VV‐ECLS: 13Fr, 16Fr, 19Fr, 20Fr and 23Fr) at 36°C. Real‐time pressure and flow data were recorded for analysis. The use of a small‐caliber venous cannula significantly increased the venous line pressure in the 2 pediatric circuits ( P ??0.01). Shorter venous tubing lengths significantly reduced the venous line pressure at high flow rates ( P ??0.01). The VV‐ECLS circuit had larger negative pre‐pump pressure drops (7.2 to ?102.2?mm?Hg) when compared to the VA‐ECLS circuit (0.7 to ?60.7?mm?Hg). Selecting an appropriate venous cannula and a shorter venous tubing when feasible may significantly reduce the pressure drop of the venous line in pediatric VA‐ECLS and VV‐ECLS circuits and improve venous drainage.
机译:摘要本研究的目的是使用不同的静脉线长度和静脉套管体外寿命支持(VA-ECLS)和静脉欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲欧洲(VV-ECL)电路进行静脉线压力的体外评估。儿科VA-ECLS电路由Xenios I-Cor斜泵,Maquet Quadrox-I小儿氧化剂,塞进型生物成像动脉套管,生物型静脉套管和1/4“ID动脉管和静脉管。小儿VV-ECL电路类似,除了它包括Maquet Avalon Elite双腔双腔套管。电路含有乳酸林液和包装红细胞(血细胞比容40%)。使用不同的静脉管长度(2,4和6英尺)和套管尺寸(2,4) VA-ECL:A8FR / V10FR,A10FR / V12FR和A12FR / V14FR,VV-ECLS:13FR,16FR,19FR,20FR和23FR)在36°C。记录实时压力和流量数据进行分析。使用小口径静脉插管的使用显着增加了2个儿科电路中的静脉线压力(p≤0.01)。较短的静脉管长度在高流速速率下显着降低了静脉线压力(P≤≤0.01)。与VA-ECL电路相比(0.7至60.7mm≤mm≤MM≤MM),VV-ECLS电路具有更大的负预泵压降(7.2至102.2ΩΩmm≤mm≤mm≤mm≤mm≤mm≤mm≤mm≤mm≤mm≤mm≤mm..当可行时,选择适当的静脉套管和较短的静脉管可能会显着降低小儿VA-ECL和VV-ECLS电路中静脉线的压降,并改善静脉排水。

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