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Therapeutic effectiveness of sustained low-efficiency hemodialysis plus hemoperfusion and continuous hemofiltration plus hemoperfusion for acute severe organophosphate poisoning

机译：持续低效血液透析和连续血液过滤加上血液灌注急性严重有机磷中毒的治疗效果

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摘要

There is no report on the effects of sustained low-efficiency dialysis (SLED) plus hemoperfusion (HP) (SLED+HP) in patients with acute severe organophosphate (OP) poisoning (ASOPP). This study was designed to compare the therapeutic effectiveness between SLED+HP and continuous hemofiltration (CHF) plus HP (CHF+HP) in patients with ASOPP. In order to assess the two treatment methods, 56 patients with ASOPP were divided into CHF+HP group and SLED+HP group. The biochemical indicators, in-hospital duration, hemodynamic parameters, Acute Physiology, and Chronic Health Evaluation (APACHE II) score, and survival and mortality rates were compared. In both groups after treatment, the levels of serum creatine kinase isozyme MB, creatine kinase, creatinine, glutamic-oxalacetic transaminease, and glutamate-pyruvate transaminase, and the APACHE II scores on the first, second, and seventh day decreased (P<0.05), whereas the levels of serum acetylcholinesterase increased. The two groups showed no statistical differences in in-hospital duration, biochemical indicators, APACHE II score, hemodynamic parameters, survival rate, or the mortality rate (P>0.05). In conclusion, SLED has similar hemodynamic stability to CHF and the two treatment methods have similar effects on ASOPP patients. More importantly, SLED plus HP is relatively economical and convenient for patients with ASOPP in clinical practice.
机译：没有关于持续的低效透析（SLED）加上血液灌注（HP）（SLED + HP）在急性严重的有机磷（OP）中毒（ASOPP）患者中的影响。本研究旨在比较ASOPP患者的SLED + HP和连续血液过滤（CHF）加HP（CHF + HP）之间的治疗效果。为了评估两种治疗方法，56例ASOPP患者分为CHF + HP组和SLED + HP组。比较了生物化学指标，院内持续时间，血液动力学参数，急性生理学和慢性健康评估（APACHE II）得分以及生存和死亡率。在治疗后的两组中，血清肌酸激酶同工酶MB，肌酸激酶，肌酐，谷氨酸转氨酶和谷氨酸 - 丙酮酸转氨酶和第一个，第二天和第七天的Apache II分数降低（P <0.05 ），而乙酰胆碱酯酶的水平增加。两组在医院内持续时间，生化指标，Apache II评分，血液动力学参数，存活率或死亡率（P> 0.05）没有统计学差异。总之，雪橇具有与CHF的类似血液动力学稳定性，两种治疗方法对ASOPP患者具有类似的效果。更重要的是，雪橇加HP对临床实践中的ASOPP患者相对经济和方便。

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