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首页> 外文期刊>Artificial Organs >Outcome Improvement for Hypothermic Machine Perfusion Versus Cold Storage for Kidneys From Cardiac Death Donors
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Outcome Improvement for Hypothermic Machine Perfusion Versus Cold Storage for Kidneys From Cardiac Death Donors

机译：低温机灌注对来自心死捐赠者的肾脏冷储存的结果改进

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摘要

Organ shortage has led to an increased use of kidneys from cardiac death donors (DCDs), but controversies about the methods of organ preservation still exist. This study aims to compare the effect of machine perfusion (MP) and cold storage (CS) in protecting kidneys harvested from DCDs. 141 kidney pairs from DCDs between July 2010 and July 2015 were included in this randomized controlled study. One kidney from each donor was randomly assigned to MP and the contralateral kidney was assigned to CS. Delayed graft function (DGF) rate, resistance index of renal arteries, early renal function, and survival rates were used to estimate the effect of preservation. The results showed that MP decreased the rate of DGF from 33.3 to 22.0% (P=0.033). Ultrasound of the kidneys within 48 h after transplantation showed that the resistance index of renal main artery (0.673 +/- 0.063 vs. 0.793 +/- 0.124, P< 0.001), sub segmental artery (0.66 +/- 0.062 vs. 0.764 +/- 0.077, P< 0.001) and interlobular artery (0.648 +/- 0.056 vs. 0.745 +/- 0.111, P=0.023) were all significantly lower in the MP group than those in the CS group. Furthermore, compared to the CS group, in the first 7 days following transplantation, the median urine volume was significantly higher (4080 mL vs. 3000 mL, P=0.047) in kidneys sustained using MP and the median serum creatinine was remarkably lower (180 mmol/L vs. 390 mmol/L, P=0.024). More importantly, MP group had higher 1-and 3-year graft survival rates (98% vs. 93%, P=0.026; 93% vs. 82%, P=0.036, respectively). Hypothermic MP improved the outcomes of DCD kidney transplantation.
机译：器官短缺导致肾脏从心脏死亡捐赠者（DCD）增加使用，但是关于器官保存方法的争论仍然存在。本研究旨在比较机器灌注（MP）和冷库（CS）在保护中肾脏收获的肾脏的影响。 141来自2010年7月至2015年7月在2015年7月至2015年7月之间的DCD的肾脏对被列入了这项随机对照研究。将来自每个供体的一个肾脏随机分配给MP，对侧肾脏分配给CS。延迟接枝函数（DGF）速率，肾动脉抗性指数，早期肾功能和存活率用于估算保存的效果。结果表明，MP从33.3％降至22.0％（P = 0.033）。移植后48小时内的肾脏超声显示肾主动脉的阻力指数（0.673 +/- 0.063，0​​.793 +/- 0.124，p <0.001），亚间段动脉（0.66 +/- 0.062与0.764 + / - 0.077，P <0.001）和角间动脉（0.648 +/- 0.056，0.745 +/- 0.111，P = 0.023）在MP组中均显着低于CS组中的MP组。此外，与CS组相比，在移植后的前7天内，使用MP持续缓解的肾脏中位尿量（4080mL与3000mL，P = 0.047），中位血清肌酐非常低（180 mmol / l与390 mmol / l，p = 0.024）。更重要的是，MP组具有较高的1至3年移植物存活率（98％vs.93％，P = 0.026; 93％，分别为82％，P = 0.036）。低温MP改善了DCD肾移植的结果。

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  • 来源
    《Artificial Organs》 |2017年第7期|共7页
  • 作者

    Zhong Zibiao; Lan Jianan; Ye Shaojun; Liu Zhongzhong; Fan Lin; Zhang Yang; Fu Zhen; Qiao Bingbing; Ko Dicken Shiu-Chung; Wang Yanfeng; Ye Qifa;

  • 作者单位

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Harvard Med Sch Massachusetts Gen Hosp Dept Urol Boston MA USA;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Transplant Ctr Hubei Key Lab Med Technol;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 器官移植术;
  • 关键词

    Kidney transplantation; Machine perfusion; Donation after cardiac death; Cold storage; Delayed graft function;

    机译：肾移植;机械灌注;心脏死亡后捐赠;冷藏;延迟移植函数;

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