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A Soft Total Artificial Heart-First Concept Evaluation on a Hybrid Mock Circulation

机译：混合型循环的柔和总人造心脏第一概念评价

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摘要

The technology of 3D-printing has allowed the production of entirely soft pumps with complex chamber geometries. We used this technique to develop a completely soft pneumatically driven total artificial heart from silicone elastomers and evaluated its performance on a hybrid mock circulation. The goal of this study is to present an innovative concept of a soft total artificial heart (sTAH). Using the form of a human heart, we designed a sTAH, which consists of only two ventricles and produced it using a 3D-printing, lost-wax casting technique. The diastolic properties of the sTAH were defined and the performance of the sTAH was evaluated on a hybrid mock circulation under various physiological conditions. The sTAH achieved a blood flow of 2.2 L/min against a systemic vascular resistance of 1.11 mm Hg s/mL (afterload), when operated at 80 bpm. At the same time, the mean pulmonary venous pressure (preload) was fixed at 10 mm Hg. Furthermore, an aortic pulse pressure of 35 mm Hg was measured, with a mean aortic pressure of 48 mm Hg. The sTAH generated physiologically shaped signals of blood flow and pressures by mimicking the movement of a real heart. The preliminary results of this study show a promising potential of the soft pumps in heart replacements. Further work, focused on increasing blood flow and in turn aortic pressure is required.
机译：3D-Printing技术允许生产具有复杂室几何形状的完全软泵。我们利用这种技术开发出完全软的气动驱动的总人造心脏，来自硅氧烷弹性体，并评估其在混合型循环上的性能。本研究的目标是提出一种柔和的人造心脏（STAH）的创新概念。使用人体形式，我们设计了一个STAH，它仅由两个心室组成，并使用3D印刷丢失的蜡铸造技术制作。定义了STAH的舒张性能，并在各种生理条件下对杂交型循环进行评价STAH的性能。当在80bpm下操作时，STAH抵抗1.11mm Hg S / ml（余载）的全身血管阻力的血流。同时，平均肺部静脉压（预载）固定在10mm Hg。此外，测量35mm Hg的主动脉脉冲压力，平均主动脉压力为48mm Hg。 STAH通过模仿真核的运动来产生生理形状的血流和压力的信号。该研究的初步结果表明，心脏置换中软泵的有希望的潜力。进一步的工作，重点关注增加血液流动并倒闭主动脉压力。

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