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首页> 外文期刊>Artificial Organs >Filter Adsorption of Anidulafungin to a Polysulfone‐Based Hemofilter During CVVHD In Vitro
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Filter Adsorption of Anidulafungin to a Polysulfone‐Based Hemofilter During CVVHD In Vitro

机译：过滤anidulafungin在体外CVVHD期间的聚砜基血液氧化剂的吸附

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Abstract Candidemia is frequent in critically ill patients, especially in combination with an acute kidney injury (AKI). Echinocandins generally are recommended for therapy of such infections. Recent studies found no need for dosage adjustment in patients with end‐stage renal disease receiving hemodialysis, or patients with AKI receiving continuous venovenous hemofiltration. The aim of this in vitro study was to examine the adsorption of anidulafungin to the surface of the hemofilter during continuous venovenous hemodialysis (CVVHD) and its effect on anidulafungin concentrations. The concentration of anidulafungin in the dialyzed fluid, and the dialysate during CVVHD in vitro was examined using three different dialyzed fluids (saline; saline with 40 g/L human albumin; and a mixture of human erythrocytes and fresh frozen plasma). After the end of dialysis, the hemofilter was opened and portions of the filter capillaries were also analyzed to determine the amount of anidulafungin adsorbed. When dialyzing saline, about 99% of the anidulafungin used adsorbed to the hemofilter capillaries; in the experiments with saline with 40 g/L albumin, about 60% adsorbed to the hemofilter's surface, and when blood was dialyzed, 35% was found adsorbed after analyzing the filter capillaries. Anidulafungin was not detectable in the dialysate of any of the experiments, consequently the dialysis clearance was 0 mL/min. In conclusion, during CVVHD in vitro we found remarkable adsorption of anidulafungin to the hemofilter's surface, yet the effect on the tissue concentration needs further examination.
机译：摘要念珠菌患者在危重患者中经常频繁，特别是与急性肾损伤（AKI）组合。海螺腈通常被推荐用于治疗此类感染。最近的研究发现，在接受血液透析的终末期肾病患者中，或AKI患者接受连续的近代血液过滤器的患者的剂量调节不需要。这种体外研究的目的是在连续静脉血液透析（CVVHD）期间检查anidulafungin对血液过滤器表面的吸附及其对Anidulafungin浓度的影响。使用三种不同的透析液（盐水;用40g / L人白蛋白的盐水中的透析液中Anidulafungin的浓度和在体外CVVHD期间的透析液;和人红细胞和新鲜冷冻血浆的混合物。在透析结束后，打开血液过滤器，还分析了过滤毛细血管的部分以确定吸附的Anidulafungin的量。当透析盐水中，约99％的anidulafungin被吸附在血液过滤毛细血管上;在具有40g / L白蛋白的盐水的实验中，约60％吸附到血液过滤器的表面，并且当血液被透析时，发现35％在分析过滤毛细血管后吸附。在任何实验的透析液中没有检测到anidulafungin，因此透析清除为0 ml / min。总之，在体外CVVHD期间，我们发现显着的Anidulafungin对血液过滤器的表面吸附，但对组织浓度的影响需要进一步检查。

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