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首页> 外文期刊>Artificial Organs >The adsorption of vancomycin by polyacrylonitrile, polyamide, and polysulfone hemofilters.
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The adsorption of vancomycin by polyacrylonitrile, polyamide, and polysulfone hemofilters.

机译：聚丙烯腈，聚酰胺和聚砜滤血器对万古霉素的吸附。

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摘要

The aim of this study was to characterize vancomycin adsorption by polyacrylonitrile (PAN), polyamide, and polysulfone hemofilters using an in vitro model of hemofiltration. Vancomycin (36 mg) was added to a blood-crystalloid mixture of known volume (target concentration of 50 mg/L) and pumped around a closed circuit. Adsorption, which was calculated from the fall in concentration over 120 min, was significantly greater by 0.6-m(2) PAN filters (10.08 +/- 2.26 mg) than by 0.6-m(2) polyamide (5.20 +/- 1.82 mg) or 0.7-m(2) polysulfone (4.80 +/- 2.40 mg) filters (P < 0.05). Cumulative adsorption was not changed by the addition of 500-mL lactated Ringer's solution (to reduce the circulating vancomycin concentration). These data show that although adsorption of vancomycin by PAN, polyamide, and polysulfone hemofilters occurs, the absolute adsorption is small. Adsorption is dependent on filter material and is not reversed by a decrease in circulating concentration.
机译：这项研究的目的是使用体外血液过滤模型来表征聚丙烯腈（PAN），聚酰胺和聚砜血液过滤器对万古霉素的吸附。将万古霉素（36 mg）添加到已知体积（目标浓度为50 mg / L）的晶体晶体混合物中，并泵入闭合回路。由浓度下降120分钟计算得出的吸附量，0.6-m（2）PAN过滤器（10.08 +/- 2.26 mg）明显大于0.6-m（2）聚酰胺（5.20 +/- 1.82 mg ）或0.7-m（2）的聚砜（4.80 +/- 2.40 mg）过滤器（P <0.05）。通过添加500 mL乳酸林格氏液（以降低循环万古霉素浓度），累积吸附不会改变。这些数据表明，尽管发生了PAN，聚酰胺和聚砜滤血器对万古霉素的吸附，但绝对吸附很小。吸附取决于过滤材料，并且不会因循环浓度降低而逆转。

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