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首页> 外文期刊>Artificial Organs >In Vitro Hemodynamic Evaluation of an Adult Pulsatile Extracorporeal Membrane Oxygenation System
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In Vitro Hemodynamic Evaluation of an Adult Pulsatile Extracorporeal Membrane Oxygenation System

机译：体外血流动力学评价成人脉动体外膜氧合体系

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Abstract The objective of this study was to evaluate a pulsatile extracorporeal membrane oxygenation (ECMO) system in terms of hemodynamic energy generation and transmission under various pulsatile amplitudes, flow rates, and pseudopatient pressures in a simulated adult ECMO circuit. Surplus hemodynamic energy (SHE), a measure of the quality of pulsatility, was used to quantify pulsatile flow. The circuit consisted of an i‐cor diagonal pump, an adult XLung oxygenator, a 21 Fr Medtronic Biomedicus femoral arterial cannula, a 23/25 Fr Sorin RAP femoral venous cannula, and 3/8 in ID tubing for both arterial and venous lines. The circuit was primed with lactated Ringer's solution and then packed red blood cells (hematocrit 37%). Trials were conducted at 36°C with flow rates of 2‐5 L/min (1 L/min increments) under nonpulsatile and pulsatile mode with pulsatile amplitudes of 1000–5000 rpm (1000 rpm increments). The pseudopatient pressure was maintained at 40–100 mm Hg (20 mm Hg increments). Real‐time pressure and flow data were recorded for analysis using a custom‐made data acquisition system. There was no SHE generated by the pump under nonpulsatile mode. Under pulsatile mode, SHE levels increased with increasing pulsatile amplitude and pseudopatient pressure ( P ??0.01) but decreased with increasing flow rate. SHE levels were significantly higher at flow rates of 2–4 L/min. In addition, the XLung oxygenator had acceptable pressure drops (36.1–104.9 mm Hg) and percentages of total hemodynamic energy loss (19.6–43.9%) during all trials. The novel pulsatile ECMO system can create nonpulsatile and pulsatile flow in an adult ECMO model. However, pulsatility gradually weakened with increasing flow rates. Pulsatile amplitude settings were found to have a great impact on pulsatility.
机译：摘要本研究的目的是在模拟成年ECMO电路中的各种脉动幅度，流速和假障碍下的血流动力能量产生和透射方面评估脉动体外膜氧合（ECMO）系统。剩余血液动力学能量（她），脉动质量的衡量标准，用于量化脉动流。该电路由I-Cor斜泵，成人Xlung氧化器，A 21 fR Medtronic BiomeDiccus股动脉套管，A 23/25 FR Sorin RAP股骨静脉套管，以及动脉和静脉线的ID管中的3/8。该电路用乳酸林液溶液灌注，然后包装红细胞（血细胞比容37％）。在非分散和脉动模式下，在36°C下在36℃下进行试验，其流量为2-5升/分钟（1升/分钟），脉动幅度为1000-5000rpm（1000rpm增量）。假障压力以40-100mm Hg（20mM Hg增量）保持。使用定制数据采集系统记录实时压力和流量数据以进行分析。在非分娩模式下，泵没有她产生的。在脉动模式下，她的水平随着脉动幅度和假障碍的增加而增加（p≤≤0.01），但随着流速的增加而降低。在2-4升/分钟的流速下，她的水平显着提高。此外，Xlung氧化剂在所有试验中具有可接受的压降（36.1-104.9 mm Hg）和总血液动力能量损失（19.6-43.9％）的百分比。新型脉冲ECMO系统可以在成年ECMO模型中产生非分子和脉动流。然而，随着流速的增加逐渐削弱了脉动性。发现脉动幅度设置对脉动性产生很大影响。

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