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首页> 外文期刊>Artificial Organs >Elastin Stabilization Through Polyphenol and Ferric Chloride Combined Treatment for the Enhancement of Bioprosthetic Heart Valve Anticalcification
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Elastin Stabilization Through Polyphenol and Ferric Chloride Combined Treatment for the Enhancement of Bioprosthetic Heart Valve Anticalcification

机译：通过多酚和氯化铁的Elastin稳定化，用于增强生物假体心脏瓣膜静电处理

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Abstract The lifetime of bioprosthetic heart valves (BHVs) is limited by the mechanical damage and calcification. The major components of BHVs are collagen and elastin. Collagen could be well protected by glutaraldehyde (GLUT) crosslinking, while elastin is not stabilized and has a high risk of degradation, which could lead to the calcification of BHVs. We aimed to develop methods for stabilizing elastin and decreasing calcification. We investigated the combined tannic acid (TA) or epigallocatechin gallate (EGCG) with ferric chloride to stabilize elastin and prevent calcification. We found that the amount of TA/EGCG bound to elastin was in a time‐dependent pattern and this reaction showed better efficiency in acidic condition and ethanol‐water mixed solvents. Moreover, Fe 3+ could compete with Ca 2+ to bind to polyphenol, which could reduce the calcium deposition on BHVs. Cytotoxicity test showed that all extracts from different treatments had similar cell viabilities (85–100%). Through the combined treatments of polyphenol and ferric chloride, the pericardium had a better resistance to elastase degradation and more excellent anticalcification performance.
机译：摘要生物假体心脏瓣膜（BHV）的寿命受到机械损伤和钙化的限制。 BHV的主要成分是胶原蛋白和弹性蛋白。胶原蛋白可以通过戊二醛（露出）交联良好保护，而弹性蛋白没有稳定并且具有高的降解风险，这可能导致BHV的钙化。我们旨在开发用于稳定弹性蛋白和降低钙化的方法。我们研究了与氯化铁（EGCG）的合并单宁酸（TA）或EPigallocateChin，以稳定弹性蛋白并预防钙化。我们发现，与弹性蛋白结合的Ta / EGCG的量以时间依赖于时间的图案，并且该反应显示出更好的酸性条件和乙醇 - 水混合溶剂的效率。此外，Fe 3+可以与Ca 2+竞争以结合多酚，这可以减少BHV上的钙沉积。细胞毒性试验表明，来自不同处理的所有提取物具有类似的细胞活性（85-100％）。通过多酚和氯化铁的组合处理，心包具有更好的抗弹性蛋白酶降解和更优异的抗静电性能。

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