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首页> 外文期刊>Artificial Organs >Effects of Plasma Proteins on the Transport and Surface Characteristics of Polysulfone/Polyethersulfone and Asymmetric Cellulose Triacetate High Flux Dialyzers
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Effects of Plasma Proteins on the Transport and Surface Characteristics of Polysulfone/Polyethersulfone and Asymmetric Cellulose Triacetate High Flux Dialyzers

机译：血浆蛋白对聚砜/聚醚砜和不对称纤维素三乙酸高通透析器的运输和表面特征的影响

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Abstract Blood‐membrane interactions can have a large impact on the performance of hemodialysis membranes, particularly for high flux membranes in which the membrane itself provides very low resistance to solute transport. The objective of this study was to examine the effects of exposure to serum on the solute clearance and convective sieving characteristics of high flux polysulfone (Optiflux F250NR), polyethersulfone (ELISIO‐25H), and asymmetric cellulose triacetate (SOLACEA‐25H) hemodialyzers using both vitamin B 12 and a range of polydisperse dextrans. Zeta potential measurements were used to obtain additional insights into the changes in membrane surface properties. Exposure to serum in a simulated dialysis session caused a significant reduction in both solute clearance and sieving coefficients for the polysulfone/polyethersulfone dialyzers, particularly for the larger molecular weight solutes. In contrast, the transport characteristics of the asymmetric cellulose triacetate dialyzers were almost unchanged after exposure to serum. The zeta potential of the cellulose triacetate membrane became slightly more negative after exposure to serum, consistent with an adsorbed protein layer composed largely of albumin. The net result is that the asymmetric cellulose triacetate dialyzer had dramatically higher clearance of the larger dextrans after exposure to serum, with the clearance and sieving coefficient for a 10 kDa molecular weight dextran being more than an order of magnitude greater than that of the polysulfone/polyethersulfone membranes. These results provide important insights into the expected clinical performance of these high flux dialyzers.
机译：摘要血膜相互作用会对血液透析膜的性能产生很大影响，特别是对于高通量膜，其中膜本身提供非常低的溶质转运的抗性。本研究的目的是检测暴露于血清对高通量多砜（OPTIFLUM F250NR），聚醚砜（ELISIO-25H）和不对称纤维素三乙酸（Solacea-25H）血液赎出人的溶质间隙和对流筛分特性的影响维生素B 12和一系列多分散葡聚糖。 Zeta电位测量用于获得膜表面性能变化的额外见解。在模拟透析会期中暴露于血清，导致聚砜/聚醚砜透析器的溶质间隙和筛分系数显着降低，特别是对于较大的分子量溶质。相反，在暴露于血清后，非对称纤维素三乙酸透析器的传输特性几乎不变。在暴露于血清后，纤维素三乙酸膜的Zeta电位变得稍微较为阴性，与主要由白蛋白组成的吸附蛋白质层一致。净结果是，不对称纤维素三乙酸透析器在暴露于血清后，较大的葡聚糖的间隙较高，随着10kDa的分子量葡聚糖的间隙和筛分系数大于多砜/的数量级。聚醚砜膜。这些结果对这些高通量透析器的预期临床表现提供了重要的见解。

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