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首页> 外文期刊>Artificial Organs >The Effect of On‐Line Hemodiafiltration, Vegetarian Diet, and Urine Volume on Advanced Glycosylation End Products Measured by Changes in Skin Auto‐Fluorescence
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The Effect of On‐Line Hemodiafiltration, Vegetarian Diet, and Urine Volume on Advanced Glycosylation End Products Measured by Changes in Skin Auto‐Fluorescence

机译：在线血液过滤，素食和尿量对先进的糖基化末端产品的影响，通过皮肤自动荧光的变化测量

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Abstract Increasing urea clearance by hemodialysis (HD) has not improved patient survival. Hemodiafiltration (HDF) has been reported to reduce cardiovascular mortality. HDF increases middle sized solute clearances. Advanced glycosylation end products (AGEs) are associated with increased cardiovascular mortality. We wished to?determine whether HDF reduces AGEs. Skin auto‐fluorescence (SAF) measures circulating AGEs deposited in the skin. We compared SAF measurements 12 months apart in high flux HD and HDF patients. At enrollment SAF was not different (HD 3.34?±?0.71 vs. HDF 3.48?±?1.05 AU). At seven months after completion of SAF measurement, one hemodiafiltration center returned to hemodialysis, and one hemodialysis center converted to hemodiafiltration. In the 66 patients treated solely by high flux HD, SAF increased (3.36?±?0.71 to 3.82?±?0.88 AU, P ??0.001), whereas there was no change for 47 exclusively treated by HDF (3.45?±?1.13 to 3.44?±?0.85 AU, P ??0.9). SAF increased in 34 patients switching from HDF to high flux HD (3.52?±?0.94 vs. 3.88?±?1.05, P ??0.05), with no significant change for 33 patients converting from high flux HD to HDF (3.32?±?0.72 to 3.48?±?1.07 AU, P ??0.3). On multivariate analysis, SAF was associated with older age (β coefficient 0.013, P ?=?0.002), prescription of insulin (β?0.29, P ?=?0.016), lanthanum (β 0.36, P ?=?0.004), and warfarin (β 0.62, P ?=?0.012), whereas vegetarian diet and??250 mL/day residual urine volume were negatively associated with SAF (β ?0.58, P ?=?0.002 and β ?0.26, P ?=?0.033 respectively). Residual urine output and vegetarian diet were associated with lower AGE deposition. Whereas SAF increased over time in patients treated with high flux HD, there was no statistical change in SAF in those exclusively treated by HDF.
机译：摘要提高血液透析（HD）的尿素清除尚未改善患者存活。据报道，血液透析（HDF）降低了心血管死亡率。 HDF增加了中型溶质间隙。先进的糖基化终产物（年龄）与心血管死亡率增加有关。我们希望？确定HDF是否减少年龄。皮肤自动荧光（SAF）措施循环患者沉积在皮肤中。我们将SAF测量与高通量HD和HDF患者分开12个月。在注册SAF不不同（HD 3.34？±0.71 Vs. HDF 3.48？±1.05 AU）。在完成SAF测量后七个月，一个血液透析中心返回血液透析，一个血液透析中心转化为血液透析。在66名患者中仅通过高通量HD处理，SAF增加（3.36？±0.71至3.82？±0.88AU，P？<0.001），而47只能通过HDF处理47（3.45？± ？1.13至3.44？±0.85 AU，P？＆？0.9）。 SAF在34名从HDF转换为高通量HD（3.52？±0.94 Vs.3.88，p≤≤0.05），33例从高通量HD转换为HDF（3.32 ？±0.72至3.48？±1.07 au，p？0.3）。在多变量分析中，SAF与较旧的年龄（β系数0.013，p？0.002），胰岛素的处方（β？0.29，p？0.016），镧（β0.36，p？= 0.004），和Warfarin（β0.62，p？= 0.012），而素食饮食和Δ＆？250ml /天残留的尿量与saf呈负相关（β〜0.58，p？0.002和β0.26，p？0.26，p？0.26，p？= 0.26，p？= 0.26，p？= 0.26 ？0.033分别）。残留的尿量输出和素食饮食与较低的年龄沉积有关。虽然SAF随着高通量HD处理的患者而增加，但在HDF专门治疗的人中没有统计变化。

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