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首页> 外文期刊>Acta Psychiatrica Scandinavica >Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?
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Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?

机译：抑郁症患者的血小板MAO-B活性是否与自杀和行为人格特质相关？

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OBJECTIVE: Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls. METHOD: In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode - MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA -'suicide attempters'), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA -'non-suicide attempters'). RESULTS: The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a singlefinding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed. CONCLUSION: Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated.
机译：目的：血小板单胺氧化酶B（MAO-B）活性低与多种形式的冲动行为和自杀倾向有关。本研究调查了抑郁症患者和对照组中血小板MAO-B活性与自杀状态之间的关系。方法：在87例情感光谱障碍患者（58％患有严重抑郁发作-MDE）中，检查了血小板MAO-B活性与自杀性之间的潜在关联。最近有59名患者尝试过自杀（SA-“自杀未遂”），过去有28名患者严重抑郁，没有表现出自杀念头或自杀行为（NA-“非自杀未遂”）。结果：SA和NA在诊断，一般人口统计学和心理病理学参数方面具有可比性。 SA和NA之间的MAO-B活性没有差异。在MAO-B活动与任何自杀行为或精神​​病理学维度之间没有系统的相关性。作为单项发现，仅观察到SA中较高的MAO-B活性与SA的致命意图的弱正相关。结论：我们的发现并不支持血小板MAO-B活性与自杀行为的一致性，但可能与自杀有关。

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