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首页> 外文期刊>Acta Psychiatrica Scandinavica >Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder.
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Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder.

机译：在重度抑郁症中，易怒与焦虑和严重程度相关，但与双极谱特征无关。

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OBJECTIVE: Irritability is common during major depressive episodes, but its clinical significance and overlap with symptoms of anxiety or bipolar disorder remains unclear. We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD). METHOD: Logistic regression was used to identify features associated with presence of irritability on the clinician-rated Inventory of Depressive Symptomatology. RESULTS: Of 2307 study participants, 1067(46%) reported irritability at least half the time during the preceding week; they were more likely to be female, to be younger, to experience greater depression severity and anxiety, and to report poorer quality of life, prior suicide attempts and suicidal ideation. Bipolar spectrum features were not more common among those with irritability. CONCLUSION: Irritable depression is not a distinct subtype of MDD, but irritability is associated with greater overall severity, anxiety comorbidity and suicidality.
机译：目的：烦躁情绪在重度抑郁发作中很常见，但其临床意义以及与焦虑症或双相情感障碍症状的重叠仍不清楚。我们在具有重性抑郁症（MDD）的缓解抑郁症（STAR * D）研究参与者的测序治疗替代方案的确证队列中研究了易怒性的临床相关性。方法：在临床医师评定的抑郁症状量表上，采用逻辑回归分析确定与易怒性相关的特征。结果：在2307名研究参与者中，有1067名（46％）报告说烦躁性至少是前一周的一半。他们更有可能是女性，更年轻，经历更大的抑郁症严重程度和焦虑感，并报告生活质量较差，曾尝试过自杀和自杀意念。在易怒者中，双极频谱特征并不普遍。结论：易怒性抑郁不是MDD的独特亚型，但易怒性与总体严重程度，焦虑合并症和自杀性相关。

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