Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions

Li Wenming; Yang Qian; Mao Zixu

首页> 外文期刊>Autophagy >Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions

【24h】

Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions

机译：压力条件下内质网的伴伴伴伴伴伴伴伴伴蛋白介导的自噬的信号和诱导

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Chaperone-mediated autophagy (CMA), a form of selective autophagy, maintains cellular proteostasis in response to diverse stress conditions. Whether and how endoplasmic reticulum (ER) stress triggers CMA remains elusive. In our recent study, we demonstrate that various types of ER stress activate the CMA pathway via an EIF2AK3/PERK-MAP2K4/MKK4-MAPK14/p38-dependent manner. We term this process ERICA for ER stress-induced chaperone-mediated autophagy. This pathway is activated in response to stress associated with Parkinson disease and is required for the viability of the SNc dopaminergic neurons in an animal model of Parkinson disease.

机译：伴侣介导的自噬（CMA）是一种选择性自噬的形式，保持细胞蛋白质响应于不同的应力条件。无论是如何以及如何压力触发CMA仍然难以捉摸。在我们最近的研究中，我们证明各种类型的ER应力通过EIF2AK3 / PERK-MAP2K4 / MKK4-MAPK14 / P38依赖性方式激活CMA途径。我们术语术语erica erica用于ER应激诱导的伴侣介导的自噬。该途径响应于与帕金森病相关的应力而激活，并且是SNC多巴胺能神经元在帕金森病的动物模型中的活力所必需的。

著录项

来源
《Autophagy》 |2018年第6期|共3页
作者
Li Wenming; Yang Qian; Mao Zixu;
展开▼
作者单位

Emory Univ Sch Med Dept Pharmacol Atlanta GA 30322 USA;

Fourth Mil Med Univ Tangdu Hosp Dept Neurosurg Xian Shaanxi Peoples R China;

Emory Univ Sch Med Dept Pharmacol Atlanta GA 30322 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类预防医学、卫生学;
关键词
CMA; ER stress; p38 MAPK; Parkinson's disease; PERK;

机译：CMA;ER压力;P38 MAPK;帕金森病;PERK;

相似文献

外文文献
中文文献
专利

1. Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions [J] . Li Wenming, Yang Qian, Mao Zixu Autophagy . 2018,第6期

机译：压力条件下内质网的伴伴伴伴伴伴伴伴伴蛋白介导的自噬的信号和诱导
2. Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells [J] . Doaa M. Ali, Shariq S. Ansari, Michael Zepp, Cell death discovery. . 2019,第1期

机译：Optineurin下调诱导内质网胁迫，伴侣介导的自噬，胰腺癌细胞凋亡
3. Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. [J] . Choi CH, Jung YK, Oh SH Molecular pharmacology. . 2010,第1期

机译：辣椒素在恶性人乳腺细胞中的自噬诱导受p38和细胞外信号调节的丝裂原活化蛋白激酶的调控，并通过抑制内质网应激介导的细胞凋亡来延迟细胞死亡。
4. Integrative transcriptomic analysis of two cell lines elucidates the architecture of endoplasmic reticulum stress signaling in glioblastoma [C] . Chatziioannou Aristotelis A., Papadodima Olga, Dejeans Nicolas, IEEE International Conference on Bioinformatics and Bioengineering . 2013

机译：两种细胞系的整合转录组学分析阐明了胶质母细胞瘤内质网应激信号的结构
5. Sensitization to death receptor stimuli and anchorage-dependent cell death through induction of endoplasmic reticulum stress [D] . Anyiwe, Kikanwa Brenda Lydia Hope 2011

机译：通过诱导内质网应激来敏化死亡受体刺激和锚固依赖性细胞死亡
6. Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions [O] . Wenming Li, Qian Yang, Zixu Mao 2018

机译：内质网在应激条件下信号传导和诱导伴侣介导的自噬
7. Sevoflurane post-conditioning alleviated hypoxic-ischemic brain injury in neonatal rats by inhibiting endoplasmic reticulum stress-mediated autophagy via IRE1 signalings [O] . Jiayuan Niu, Ziyi Wu, Hang Xue, 2021

机译：通过通过IS1信号抑制内质网胁迫介导的自噬，七氟醚在新生大鼠中缓解了新生儿大鼠的缺氧缺血性脑损伤

Signaling and induction of chaperone-mediated autophagy by the endoplasmic reticulum under stress conditions

摘要

著录项

相似文献

相关主题

期刊订阅