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首页> 外文期刊>Acta Radiologica >MDCT has the potential to predict percutaneous coronary intervention outcome in swine model: microscopic validation.
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MDCT has the potential to predict percutaneous coronary intervention outcome in swine model: microscopic validation.

机译：MDCT具有预测猪模型中经皮冠状动脉介入治疗效果的潜力：显微镜验证。

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Background Volumes and sizes of dislodged coronary microemboli vary during PCI so their effects at the left ventricular (LV) and cellular levels cannot be quantified. Furthermore, biopsy for tissue characterization is not an option in PCI patients. Purpose To characterize and validate microinfarct size, LAD territory where microinfarct were found using multidetector computed tomography (MDCT), histochemical staining and microscopy as a function of microemboli volumes and to scale the effects of microemboli volumes on LV function. Material and Methods Under X-ray guidance, a 3F catheter was inserted into LAD coronary artery of 14 pigs for delivering 16 mm(3) or 32 mm(3) of 40-120 μm microemboli. MDCT imaging/histochemical staining/microscopy were performed 3 days later and used to characterize regional and global structural and functional changes in LV by threshold/planimetric methods. Results MDCT and ex-vivo methods were able to quantify microinfarct size and LAD territory where microinfarct was found as a function of volumes. However, MDCT and histochemical staining significantly underestimated microinfarct size and territory where microinfarct was found compared with microscopy. MDCT demonstrated the functional changes and showed a moderate correlation between LV ejection fraction and microinfarct size (r = 0.53). Microscopy provided higher spatial resolution for measuring islands of necrotic cells, which explains the difference in measuring structural changes. Conclusion MDCT showed the difference in microinfarct size and LAD territory as a function of microemboli volumes and scaled the changes in LV function. This experimental study gives clinicians a reference for the effects of defined microemboli volumes on myocardial viability and LV function and the under-estimation of microinfarct on MDCT.
机译：背景在PCI期间，移出的冠状动脉微栓塞的体积和大小会有所不同，因此无法量化它们在左心室（LV）和细胞水平上的作用。此外，在PCI患者中无法进行组织表征活检。目的为了表征和验证微梗塞的大小，使用多探测器计算机断层扫描（MDCT），组织化学染色和显微镜检查发现微梗塞的LAD区域作为微栓塞体积的函数，并衡量微栓塞体积对LV功能的影响。材料和方法在X射线引导下，将3F导管插入14头猪的LAD冠状动脉中，以递送16 mm（3）或32 mm（3）的40-120μm微栓子。 3天后进行MDCT成像/组织化学染色/显微镜检查，并用于通过阈值/平面方法表征LV的区域和整体结构和功能变化。结果MDCT和离体方法能够量化微梗塞的大小和发现微梗塞的LAD区域与体积的关系。但是，与显微镜相比，MDCT和组织化学染色显着低估了微梗塞的大小和发现微梗塞的区域。 MDCT显示功能改变，并显示左室射血分数与微梗死面积之间存在中等相关性（r = 0.53）。显微镜为测量坏死细胞岛提供了更高的空间分辨率，这解释了测量结构变化的差异。结论MDCT显示微梗死面积和LAD区域的差异是微栓塞体积的函数，并缩小了LV功能的变化。这项实验研究为确定微栓子体积对心肌生存力和左室功能的影响以及对MDCT的微梗塞估计不足提供了参考。

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