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首页> 外文期刊>Acta Radiologica >Multidetector computed tomography for characterization of calcium deposits in reperfused myocardial infarction.
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Multidetector computed tomography for characterization of calcium deposits in reperfused myocardial infarction.

机译：多探测器计算机断层扫描技术用于表征再灌注心肌梗死中的钙沉积。

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BACKGROUND: Calcium overload is a major cause of reperfusion myocardial injury. Multidetector computed tomography (MDCT) has been previously used in visualizing coronary artery calcium, but not calcium deposits in reperfused infarction. PURPOSE: To assess the ability of MDCT to 1) noninvasively visualize and characterize calcium deposits in reperfused infarcts, and 2) monitor regional wall swelling, regional systolic wall thickening, and infarct resorption. MATERIAL AND METHODS: Reperfused myocardial infarcts were created in seven pigs by 2-hour occlusion of the left anterior descending coronary artery (LAD) after coronary catheterization. A 64-slice MDCT scanner was used for non-contrast images to depict calcium deposits. Furthermore, cine and delayed contrast-enhanced (DE) MDCT imaging were acquired to assess the chronological changes (2-4 hours, 1 week, and 8 weeks) in regional wall swelling, systolic wall thickening, and infarct size. RESULTS: Non-contrast MDCT images depicted calcium deposits as "hot-spots." Attenuation of calcium deposits was greater (89+/-6 Hounsfield units [HU]) than remote myocardium (36+/-3 HU; P<0.05). Calcium deposits were not evident at 2-4 hours and were substantially smaller at 8 weeks compared to 1 week. Correlations were found between the extent of calcium deposits, ejection fraction (R=0.81), and infarction size (R=0.70). Cine MCDT images demonstrated transient wall swelling (edema formation and resorption) at 2-4 hours and differences in regional systolic wall thickening among infarcted, peri-infarcted, and remote myocardium. Calcium-specific von Kossa stain confirmed the presence of calcium deposits in infarcted myocardium. CONCLUSION: 64-slice MDCT has the potential to demonstrate the progression and regression of calcium deposits, interstitial edema, and infarction. The presence of calcium deposits was transient and associated with reperfused recent infarction. The extent of calcium deposits was positively correlated with infarction size and negatively with global left-ventricular function.
机译：背景：钙超载是再灌注心肌损伤的主要原因。先前已使用多探测器计算机断层扫描（MDCT）来显示冠状动脉钙，但不能观察到再灌注梗塞中的钙沉积。目的：评估MDCT的能力：1）无创地观察和表征再灌注梗塞中的钙沉积，以及2）监测区域壁肿胀，区域收缩壁增厚和梗死吸收。材料与方法：7只猪在进行冠状动脉导管插入术后2个小时阻塞了左前降支冠状动脉（LAD），造成了再灌注心肌梗塞。 64层MDCT扫描仪用于非对比图像以描绘钙沉积。此外，获得了电影和延迟对比增强（DE）MDCT成像来评估区域性壁肿胀，收缩期壁增厚和梗死面积的时间变化（2-4小时，1周和8周）。结果：非对比MDCT图像将钙沉积物描述为“热点”。钙沉积物的衰减（89 +/- 6 Hounsfield单位[HU]）大于远端心肌（36 +/- 3 HU; P <0.05）。钙沉积在2-4小时不明显，而在8周时则比1周时少得多。发现钙沉积程度，射血分数（R = 0.81）和梗死面积（R = 0.70）之间存在相关性。电影MCDT图像显示2-4小时出现短暂的壁肿胀（水肿形成和吸收），并且在梗塞，周围梗塞和远端心肌之间区域收缩壁增厚有所不同。钙特异性冯·科萨（von Kossa）染色证实了梗塞心肌中钙沉积物的存在。结论：64层MDCT有潜力证明钙沉积，间质性水肿和梗塞的进展和消退。钙沉积的存在是短暂的，并且与近期再灌注的梗塞有关。钙沉积的程度与梗死面积呈正相关，与整体左心室功能呈负相关。

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