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首页> 外文期刊>Acta Radiologica >A method for quantifying intervertebral disc signal intensity on T2-weighted imaging.
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A method for quantifying intervertebral disc signal intensity on T2-weighted imaging.

机译：一种在T2加权成像上量化椎间盘信号强度的方法。

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Background Quantification of intervertebral disc degeneration based on intensity of the nucleus pulposus in magnetic resonance imaging (MRI) often uses the mean intensity of the region of interest (ROI) within the nucleus pulposus. However, the location and size of ROI have varied in different reports, and none of the reported methods can be considered fully objective. Purpose To develop a more objective method of establishing ROIs for quantitative evaluation of signal intensity in the nucleus pulposus using T2-weighted MRI. Material and Methods A 1.5-T scanner was used to obtain T2-weighted mid-sagittal images. A total of 288 intervertebral discs from 48 patients (25 men, 23 women) were analyzed. Mean age was 47.4 years (range, 17-69 years). All discs were classified into five grades according to Pfirrmann et al. Discs in grades I and II were defined as bright discs, and discs in grades IV and V were defined as dark discs. Eight candidate methods of ROI determination were devised. The method offering the highest degree of discrimination between bright and dark discs was investigated among these eight methods. Results The method with the greatest degree of discrimination was as follows. The quadrangle formed by anterior and posterior edges of the upper and lower end plates in contact with the intervertebral disc to be measured was defined as the intervertebral area. A shape similar to the intervertebral area but with one-quarter the area was drawn. The geometrical center of the shape was matched to the center of intensity, and this shape was then used as the ROI. Satisfactory validity and reproducibility were obtained using this method. Conclusion The present method offers adequate discrimination and could be useful for longitudinal tracking of intervertebral disc degeneration with sufficient reproducibility.
机译：背景基于磁共振成像（MRI）中髓核强度的椎间盘退变定量通常使用髓核内感兴趣区域（ROI）的平均强度。但是，在不同的报告中，ROI的位置和大小有所不同，没有一种报告的方法可以被认为是完全客观的。目的开发一种更客观的建立ROI的方法，以使用T2加权MRI定量评估髓核中的信号强度。材料和方法使用1.5-T扫描仪获取T2加权的中矢状图像。共分析了来自48例患者的288个椎间盘（男25例，女23例）。平均年龄为47.4岁（范围为17-69岁）。根据Pfirrmann等人的说法，所有光盘都分为五个等级。 I级和II级的光盘定义为明亮的光盘，IV级和V级的光盘定义为黑暗的光盘。设计了八种确定ROI的候选方法。在这八种方法中，研究了在明盘和暗盘之间提供最高区分度的方法。结果鉴别度最高的方法如下。将由上下端板的前缘和后缘与要测量的椎间盘接触形成的四边形定义为椎间区域。绘制的形状类似于椎骨区域，但面积为四分之一。形状的几何中心与强度中心匹配，然后将此形状用作ROI。使用此方法可获得令人满意的有效性和可重复性。结论本方法提供了足够的判别力，可用于纵向追踪椎间盘退变并具有足够的可重复性。

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