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首页> 外文期刊>Acta Radiologica >Contrast medium nephrotoxicity after renal artery and coronary angioplasty.
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Contrast medium nephrotoxicity after renal artery and coronary angioplasty.

机译：肾动脉和冠状动脉成形术后造影剂肾毒性。

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BACKGROUND: Renal dysfunction induced by iodinated contrast medium (CM) administration can minimize the benefit of the interventional procedure in patients undergoing renal angioplasty (PTRA). PURPOSE: To compare the susceptibility to nephrotoxic effect of CM in patients undergoing PTRA with that of patients submitted to percutaneous coronary intervention (PCI). MATERIAL AND METHODS: A total of 33 patients successfully treated with PTRA (PTRA group, mean age 70+/-12 years, 23 female, basal creatinine 1.46+/-0.79, range 0.7-4.9 mg/dl) were compared with 33 patients undergoing successful PCI (PCI group), matched for basal creatinine (1.44+/-0.6, range 0.7-3.4 mg/dl), gender, and age. In both groups postprocedural (48 h) serum creatinine was measured. RESULTS: Postprocedural creatinine level decreased nonsignificantly in the PTRA group (1.46+/-0.8 vs. 1.34+/-0.5 mg/dl, P=NS) and increased significantly in the PCI group (1.44+/-0.6 vs. 1.57+/-0.7 mg/dl, P<0.02). Changes in serum creatinine after intervention (after-before) were significantly different between the PTRA and PCI groups (-0.12+/-0.5 vs. 0.13+/-0.3, P=0.014). This difference was not related to either a different clinical risk profile or to the volume of CM administered. CONCLUSION: In this preliminary study patients submitted to PTRA showed a lower susceptibility to renal damage induced by CM administration than PCI patients. The effectiveness of PTRA on renal function seems to be barely influenced by CM toxicity.
机译：背景：碘造影剂（CM）给药引起的肾功能不全可以使接受肾血管成形术（PTRA）的患者的介入治疗获益最小化。目的：比较接受PTRA治疗的患者与接受经皮冠状动脉介入治疗（PCI）的患者对CM的肾毒性作用的敏感性。材料与方法：将33例成功接受PTRA治疗的患者（PTRA组，平均年龄70 +/- 12岁，23例女性，基底肌酐1.46 +/- 0.79，范围0.7-4.9 mg / dl）与33例患者进行了比较接受成功的PCI（PCI组），匹配基础肌酐（1.44 +/- 0.6，范围0.7-3.4 mg / dl），性别和年龄。两组均在手术后（48小时）测量血清肌酐。结果：PTRA组术后肌酐水平无明显下降（1.46 +/- 0.8 vs. 1.34 +/- 0.5 mg / dl，P = NS），而PCI组明显升高（1.44 +/- 0.6 vs. 1.57 + / -0.7mg / dl，P ＜0.02）。 PTRA组和PCI组之间干预后（之前）的血清肌酐变化显着不同（-0.12 +/- 0.5与0.13 +/- 0.3，P = 0.014）。这种差异与不同的临床风险状况或所施用的CM量均无关。结论：在这项初步研究中，接受PTRA治疗的患者对CM引起的肾脏损害的敏感性低于PCI患者。 PTRA对肾功能的有效性似乎几乎不受CM毒性的影响。

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