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首页> 外文期刊>Advances in cancer research. >FOXM1 (Forkhead box M1) in tumorigenesis. Overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy
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FOXM1 (Forkhead box M1) in tumorigenesis. Overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy

机译：FOXM1（叉头盒M1）在肿瘤发生中。在人类癌症中的过表达，在肿瘤发生中的意义，致癌功能，肿瘤抑制特性以及抗癌治疗的靶标

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FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell cycle progression by promoting the entry into S-phase and M-phase. Additionally, FOXM1 is required for proper execution of mitosis. In accordance with its role in stimulation of cell proliferation, FOXM1 exhibits a proliferation-specific expression pattern and its expression is regulated by proliferation and anti-proliferation signals as well as by proto-oncoproteins and tumor suppressors. Since these factors are often mutated, overexpressed, or lost in human cancer, the normal control of the foxm1 expression by them provides the basis for deregulated FOXM1 expression in tumors. Accordingly, FOXM1 is overexpressed in many types of human cancer. FOXM1 is intimately involved in tumorigenesis, because it contributes to oncogenic transformation and participates in tumor initiation, growth, and progression, including positive effects on angiogenesis, migration, invasion, epithelial-mesenchymal transition, metastasis, recruitment of tumor-associated macrophages, tumor-associated lung inflammation, self-renewal capacity of cancer cells, prevention of premature cellular senescence, and chemotherapeutic drug resistance. However, in the context of urethane-induced lung tumorigenesis, FOXM1 has an unexpected tumor suppressor role in endothelial cells because it limits pulmonary inflammation and canonical Wnt signaling in epithelial lung cells, thereby restricting carcinogenesis. Accordingly, FOXM1 plays a role in homologous recombination repair of DNA double-strand breaks and maintenance of genomic stability, that is, prevention of polyploidy and aneuploidy. The implication of FOXM1 in tumorigenesis makes it an attractive target for anticancer therapy, and several antitumor drugs have been reported to decrease FOXM1 expression.
机译：FOXM1（叉头盒M1）是一种典型的与增殖相关的转录因子，也与肿瘤发生密切相关。 FOXM1通过促进进入S期和M期来刺激细胞增殖和细胞周期进程。此外，正确执行有丝分裂需要FOXM1。根据其在刺激细胞增殖中的作用，FOXM1表现出增殖特异性表达模式，其表达受增殖和抗增殖信号以及原癌蛋白和肿瘤抑制因子的调控。由于这些因素通常在人类癌症中发生突变，过表达或丢失，因此，它们对foxm1表达的正常控制为肿瘤中FOXM1表达失控提供了基础。因此，FOXM1在许多类型的人类癌症中过表达。 FOXM1密切参与肿瘤发生，因为它有助于致癌转化并参与肿瘤的发生，生长和进展，包括对血管生成，迁移，侵袭，上皮-间质转化，转移，肿瘤相关巨噬细胞募集，相关的肺部炎症，癌细胞的自我更新能力，防止细胞过早衰老和化学治疗药物耐药性。但是，在氨基甲酸酯诱导的肺肿瘤发生中，FOXM1在内皮细胞中具有意想不到的肿瘤抑制作用，因为它限制了肺部炎症和上皮肺细胞中的经典Wnt信号传导，从而限制了癌变。因此，FOXM1在DNA双链断裂的同源重组修复和基因组稳定性的维持中起作用，即，防止多倍性和非整倍性。 FOXM1在肿瘤发生中的意义使其成为抗癌治疗的有吸引力的靶标，并且已经报道了几种抗肿瘤药物可降低FOXM1的表达。

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