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Neuro-Immune Cell Units: A New Paradigm in Physiology

机译:神经免疫细胞单位:生理学的新范式

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The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environmental signals are sensed by discrete neuro-immune cell units (NICUs), which represent defined anatomical locations in which immune and neuronal cells colocalize and functionally interact to steer tissue physiology and protection. These units have now been described in multiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers. As such, NICUs are emerging as important orchestrators of multiple physiological processes, including hematopoiesis, organogenesis, inflammation, tissue repair, and thermogenesis. In this review we focus on the impact of NICUs in tissue physiology and how this fast-evolving field is driving a paradigm shift in our understanding of immunoregulation and organismal physiology.
机译:过去的免疫和神经系统之间的相互作用已被承认,但最近的研究已经开始解开这种相互作用的细胞和分子参与者。 安装证据表明,通过离散的神经免疫细胞单位(Nicus)感测环境信号,其代表了定义的解剖位置,其中免疫和神经细胞结合和功能相互作用以引导组织生理和保护。 现在已经在整个体内的多种组织中描述了这些单元,包括淋巴器官,脂肪组织和粘膜屏障。 因此,尼古斯正在成为多种生理过程的重要协调件,包括血小霉,子组织,炎症,组织修复和热生成。 在这篇综述中,我们专注于Nicus在组织生理学中的影响以及这种快速发展的领域如何在我们对免疫调节和有机体生理学的理解中推动范式转变。

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