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首页> 外文期刊>Annual Review of Immunology >Caspases in Cell Death, Inflammation, and Pyroptosis
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Caspases in Cell Death, Inflammation, and Pyroptosis

机译：细胞死亡，炎症和糊酶的胱天冬酶

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摘要

Caspases are a family of conserved cysteine proteases that play key roles in programmed cell death and inflammation. In multicellular organisms, caspases are activated via macromolecular signaling complexes that bring inactive procaspases together and promote their proximity-induced autoactivation and proteolytic processing. Activation of caspases ultimately results in programmed execution of cell death, and the nature of this cell death is determined by the specific caspases involved. Pioneering new research has unraveled distinct roles and cross talk of caspases in the regulation of programmed cell death, inflammation, and innate immune responses. In-depth understanding of these mechanisms is essential to foster the development of precise therapeutic targets to treat autoinflammatory disorders, infectious diseases, and cancer. This review focuses on mechanisms governing caspase activation and programmed cell death with special emphasis on the recent progress in caspase cross talk and caspase-driven gasdermin D-induced pyroptosis.
机译：Caspases是一家保守的半胱氨酸蛋白酶，在编程的细胞死亡和炎症中起关键作用。在多细胞生物中，通过大分子信号络合物激活胱天蛋白酶，使得使不活跃的促进酶活性并促进其邻近诱导的自动激活和蛋白水解加工。胱天蛋白酶的激活最终导致编程的细胞死亡的执行，并且这种细胞死亡的性质由所涉及的特定胱天膜确定。开创性的新研究在规则的细胞死亡，炎症和先天免疫应答的调节中，新的研究已经解开了独特的角色和跨谈的血糖。深入了解这些机制对于促进精确治疗靶标以治疗自身炎症性疾病，传染病和癌症是必不可少的。本综述重点介绍了治疗Caspase激活和编程的细胞死亡的机制，特别强调了Caspase交叉谈话和Caspase驱动的燃气蛋白D诱导的γ凋亡的最新进展。

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