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Antigen-Presenting Cells in the Skin

机译：皮肤中的抗原呈递细胞

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摘要

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with the capacity to enter skin from the peripheral circulation, patrol within tissue, and migrate through lymphatics to draining lymph nodes. Skin APCs are endowed with antigen-sensing, -processing, and -presenting machinery and play key roles in initiating, modulating, and resolving cutaneous inflammation. Skin APCs are a highly heterogeneous population with functionally specialized subsets that are developmentally imprinted and modulated by local tissue microenvironmental and inflammatory cues. This review explores recent advances that have allowed for a more accurate taxonomy of APC subsets found in both mouse and human skin. It also examines the functional specificity of individual APC subsets and their collaboration with other immune cell types that together promote adaptive T cell and regional cutaneous immune responses during homeostasis, inflammation, and disease.
机译：皮肤中的专业抗原呈递细胞（APC）包括树突细胞，单核细胞和巨噬细胞。它们具有高度动态的，具有进入外围循环，组织巡逻的皮肤的能力，并通过淋巴管迁移到排水淋巴结。皮肤APC赋予抗原感测， - 处理和 - 在启动，调节和解决皮肤炎症时发挥关键作用。皮肤APC是一种高度异质的群体，具有功能专用的子集，由局部组织微环境和炎症线本发育印迹和调节。该审查探讨了最近允许在鼠标和人类皮肤中发现的APC子集的更准确的分类。它还检查单个APC子集的功能特异性及其与其他免疫细胞类型的合作，共同促进稳态，炎症和疾病期间的适应性T细胞和区域皮肤免疫应答。

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