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首页> 外文期刊>Annual Review of Immunology >Ion Channels in Innate and Adaptive Immunity
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Ion Channels in Innate and Adaptive Immunity

机译：在先天和自适应免疫中的离子通道

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摘要

Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses. and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy.
机译：离子通道和运输司机在疏水性脂膜上介导带电离子的运输。在免疫细胞中，钙，镁和锌等二价阳离子具有重要作用，作为第二信使调节细胞内信号传导途径。相比之下，单价阳离子如钠和钾主要调节膜电位，间接地控制钙和免疫细胞信号传导的涌入。研究人类患有离子通道和转运蛋白突变的研究，基因靶向小鼠的分析，或离子通道抑制剂的药理学实验表明了离子信号在淋巴细胞发育中的重要作用以及先天和适应性免疫应答。我们在这里审查了淋巴细胞和先天免疫细胞中离子通道和转运蛋白功能的机制，并讨论了淋巴细胞发育，适应性和先天免疫应答的作用。以及自身免疫，以及最近努力开发用于免疫调节治疗的离子通道的药理抑制剂。

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