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首页> 外文期刊>Annual Review of Immunology >Transcription Factor Networks Directing the Development, Function, and Evolution of Innate Lymphoid Effectors
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Transcription Factor Networks Directing the Development, Function, and Evolution of Innate Lymphoid Effectors

机译：转录因子网络指导先天淋巴效应的开发，功能和演化

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摘要

Mammalian lymphoid immunity is mediated by fast and slow responders to pathogens. Fast innate lymphocytes are active within hours after infections in mucosal tissues. Slow adaptive lymphocytes are conventional T and B cells with clonal antigen receptors that function days after pathogen exposure. A transcription factor (TF) regulatory network guiding early T cell development is at the core of effector function diversification in all innate lymphocytes, and the kinetics of immune responses is set by developmental programming. Operational units within the innate lymphoid system are not classified by the types of pathogen-sensing machineries but rather by discrete effector functions programmed by regulatory TF networks. Based on the evolutionary history of 'ITs of the regulatory networks, fast effectors likely arose earlier in the evolution of animals to fortify body barriers, and in mammals they often develop in fetal ontogeny prior to the establishment of fully competent adaptive immunity.
机译：哺乳动物淋巴抗免疫由快速和缓慢的响应者介导的病原体。快速先天淋巴细胞在粘膜组织中感染后的几小时内活跃。缓慢的自适应淋巴细胞是常规的T和B细胞，其具有克隆抗原受体，其在病原体暴露后的功能天。转录因子（TF）调节网络引导早期T细胞发育是在所有先天淋巴细胞中效应函数多样化的核心，并且通过发育规划设定免疫应答的动力学。先天淋巴系统内的操作单元未被病原体传感机器类型的类型分类，而是由监管TF网络编程的离散效应器函数。基于“其监管网络的进化历史”，快速效果可能在动物的演变中可能出现在动物障碍物中，并且在哺乳动物中，他们在建立完全具有态度的适应性免疫之前，他们经常在胎儿形成。

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