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Immunology in the Era of Single-Cell Technologies

机译:单细胞技术时代的免疫学

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摘要

Immune cells are characterized by diversity, specificity, plasticity, and adaptability-properties that enable them to contribute to homeostasis and respond specifically and dynamically to the many threats encountered by the body. Single-cell technologies, including the assessment of transcriptomics, genomics, and proteomics at the level of individual cells, are ideally suited to studying these properties of immune cells. In this review we discuss the benefits of adopting single-cell approaches in studying underappreciated qualities of immune cells and highlight examples where these technologies have been critical to advancing our understanding of the immune system in health and disease.
机译:免疫细胞的特征在于多样性,特异性,可塑性和适应性 - 使它们能够为稳态有助于稳态,并对身体遇到的许多威胁进行特别响应。 单细胞技术,包括在单个细胞水平的转录组织,基因组学和蛋白质组学的评估,非常适合研究免疫细胞的这些性质。 在本文中,我们探讨了采用单细胞方法研究免疫细胞的低估,并强调这些技术对促进健康和疾病的理解至关重要的例子。

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