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首页> 外文期刊>Annual Review of Immunology >Antigen Receptor Function in the Context of the Nanoscale Organization of the B Cell Membrane
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Antigen Receptor Function in the Context of the Nanoscale Organization of the B Cell Membrane

机译：抗原受体在B细胞膜的纳米级组织的背景下的功能

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摘要

The B cell antigen receptor (BCR) plays a central role in the self/nonself selection of B lymphocytes and in their activation by cognate antigen during the clonal selection process. It was long thought that most cell surface receptors, including the BCR, were freely diffusing and randomly distributed. Since the advent of superresolution techniques, it has become clear that the plasma membrane is compartmentalized and highly organized at the nanometer scale. Hence, a complete understanding of the precise conformation and activation mechanism of the BCR must take into account the organization of the B cell plasma membrane. We review here the recent literature on the nanoscale organization of the lymphocyte membrane and discuss how this new information influences our view of the conformational changes that the BCR undergoes during activation.
机译：B细胞抗原受体（BCR）在B淋巴细胞的自主选择中起到核心作用，并通过同源抗原在克隆选择过程中激活。 很长时间认为，大多数细胞表面受体包括BCR，可自由扩散和随机分布。 自超级化技术的出现以来，已经清楚地清楚地，血浆膜在纳米尺度上被划分和高度组织。 因此，必须完全了解BCR的精确构象和活化机制必须考虑到B细胞血浆膜的组织。 我们在这里审查了淋巴细胞膜的纳米级组织的最近文献，并讨论了如何影响BCR在激活期间对BCR经历的构象变化的看法。

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