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首页> 外文期刊>Acta Radiologica >A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T.
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A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T.

机译：MR弹性成像在3.0T诊断前列腺癌中的可行性研究。

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Background MR elastography is a new imaging tool capable of non-invasively assessing the viscoelastic properties of tissues. The clinical application of MR elastography in the diagnosis of prostate cancer remains to be elucidated. Purpose To investigate the feasibility of MR elastography in the diagnosis of prostate cancer at 3.0T, and to assess the elasticity and viscosity of prostate cancer and benign prostatic disease. Material and Methods Eight patients (63 +/- 7.25 years old) with 12 foci of prostate cancer and 10 patients (59 +/- 3.25 years old) with 14 foci of prostatitis in the peripheral zone were evaluated by MRE. Ten healthy volunteers (41 +/- 4.32 years old) with 18 ROIs in the peripheral zone of the prostate were also assessed with MR elastography as a control group. The results were confirmed by histopathological findings. All examinations were performed on a 3.0T Philips Achieva scanner. MRE was implemented by transmitting low-frequency longitudinal mechanical waves of 100Hz into the prostate with a transducer placed above the pubic bones. The phase images were reconstructed to acquire viscoelastic mapping. T-test was used to compare the mean elasticity and viscosity of prostate cancer and prostatitis. A comparison of prostate cancer and healthy prostate tissue in elasticity was also evaluated. The correlation of elasticity and Gleason scores between prostate cancer and prostatitis were retrospectively analyzed with Pearson Correlation. Results The mean elasticity and viscosity were significantly higher in the lesions with prostate cancer (6.55 +/- 0.47 kPa, 6.56 +/- 0.99 Pa.s, respectively) than in regions with prostatitis (1.99 +/- 0.66 kPa, 2.13 +/- 0.21 Pa.s). The difference between prostate cancer and prostatitis was statistically significant (t = 19.392, p < 0.01; t = 16.372, p < 0.01). The elasticity and viscosity of the healthy peripheral zone of prostate were 2.26 +/- 0.45 kPa, 2.38 +/- 0.54 Pa.s, respectively. There also was significant difference in elasticity between prostate cancer and normal peripheral zone (t = 25.136, p < 0.01). In addition, we observed a positive correlation between Gleason scores and elasticity of the prostate cancer (r = 0.913, P < 0.01) in this study. Conclusion MR elastography can be used to visualize the difference in stiffness between prostate cancer and benign prostatic disease. It is a new imaging method with potential in the diagnosis of prostate cancer.
机译：背景技术MR弹性成像是一种新的成像工具，能够无创地评估组织的粘弹性。 MR弹性成像在前列腺癌诊断中的临床应用仍有待阐明。目的探讨MR弹性成像技术在3.0T诊断前列腺癌中的可行性，并评估前列腺癌和良性前列腺疾病的弹性和黏度。材料与方法通过MRE对8位前列腺癌12个病灶的患者（63 +/- 7.25岁）和10位前列腺炎14个病灶的患者（59 +/- 3.25岁）进行了评估。 MR弹性成像法也评估了10名健康志愿者（41 +/- 4.32岁），在前列腺周围区域有18个ROI。组织病理学结果证实了该结果。所有检查均在3.0T Philips Achieva扫描仪上进行。通过在耻骨上方放置一个换能器，将100Hz的低频纵向机械波传输到前列腺中，从而实现MRE。重建相图像以获得粘弹性映射。使用T检验比较前列腺癌和前列腺炎的平均弹性和黏度。还评估了前列腺癌和健康前列腺组织在弹性方面的比较。回顾性分析了皮尔逊相关性与前列腺癌和前列腺炎之间的弹性和格里森评分的相关性。结果前列腺癌病变的平均弹性和黏度（分别为6.55 +/- 0.47 kPa，6.56 +/- 0.99 Pa.s）显着高于前列腺炎的区域（1.99 +/- 0.66 kPa，2.13 + / -0.21 Pa.s）。前列腺癌和前列腺炎之间的差异具有统计学意义（t = 19.392，p <0.01; t = 16.372，p <0.01）。前列腺健康外围区域的弹性和粘度分别为2.26 +/- 0.45 kPa，2.38 +/- 0.54Pa.s。前列腺癌和正常外周区之间的弹性也存在显着差异（t = 25.136，p <0.01）。另外，在这项研究中，我们观察到格里森评分与前列腺癌的弹性之间存在正相关（r = 0.913，P <0.01）。结论MR弹性成像可用于可视化前列腺癌与良性前列腺疾病之间的硬度差异。这是一种在前列腺癌诊断中具有潜力的新成像方法。

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