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首页> 外文期刊>Acta Radiologica >Feasibility of epicardial adipose tissue quantification in non-ECG-gated low-radiation-dose CT: Comparison with prospectively ECG-gated cardiac CT
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Feasibility of epicardial adipose tissue quantification in non-ECG-gated low-radiation-dose CT: Comparison with prospectively ECG-gated cardiac CT

机译：非心电门控低辐射剂量CT中心外膜脂肪组织定量的可行性：与前瞻性心电门控心脏CT的比较

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Background: Epicardial adipose tissue (EAT) is an important indicator of cardiovascular risk. This parameter is generally assessed on ECG-gated computed tomography (CT) images. Purpose: To evaluate feasibility and reliability of EAT quantification on non-gated thoracic low-radiation-dose CT examinations with respect to prospectively ECG-gated cardiac CT acquisition. Material and Methods: Sixty consecutive asymptomatic smokers (47 men; mean age 64±9.8 years) underwent low-dose CT of the chest and prospectively ECG-gated cardiac CT acquisitions (64-slice dual-source CT). The two examinations were reconstructed with the same range, field of view, slice thickness, and convolution algorithm. Two independent observers blindly quantified EAT volume using commercially available software. Data were compared with paired sample Student t-test, concordance correlation coefficients (CCC), and Bland-Altman plots. Results: No statistically significant difference was observed for EAT volume quantification with low-dose-CT (141.7±58.3 mL) with respect to ECG-gated CT (142.7±57.9 mL). Estimation of CCC showed almost perfect concordance between the two techniques for EAT-volume assessment (CCC, 0.99; mean difference, 0.98±5.1 mL). Inter-observer agreement for EAT volume estimation was CCC: 0.96 for low-dose-CT examinations and 0.95 for ECG-gated CT. Conclusion: Non-gated low-dose CT allows quantifying EAT with almost the same concordance and reliability as using dedicated prospectively ECG-gated cardiac CT acquisition protocols.
机译：背景：心外膜脂肪组织（EAT）是心血管风险的重要指标。通常在ECG门控计算机断层扫描（CT）图像上评估此参数。目的：就前瞻性ECG门控心脏CT采集，评估EAT定量在非门诊胸低辐射剂量CT检查中的可行性和可靠性。材料和方法：60例连续无症状吸烟者（47名男性，平均年龄64±9.8岁）接受了低剂量的胸部CT扫描和预期的ECG门控心脏CT采集（64层双源CT）。使用相同的范围，视野，切片厚度和卷积算法重建了这两个检查。两名独立的观察者使用市售软件盲目量化了EAT量。将数据与成对的样本学生t检验，一致性相关系数（CCC）和Bland-Altman图进行比较。结果：相对于ECG门控CT（142.7±57.9 mL），低剂量CT（141.7±58.3 mL）的EAT体积定量无统计学意义。 CCC的估计显示了两种用于EAT量评估的技术之间几乎完美的一致性（CCC，0.99;平均差异，0.98±5.1 mL）。 EAT量估计的观察者间共识为CCC：低剂量CT检查为0.96，ECG门控CT为0.95。结论：非门控低剂量CT可以定量量化EAT，其一致性和可靠性与使用专用的前瞻性ECG门控心脏CT采集方案几乎相同。

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