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首页> 外文期刊>Acta Radiologica >Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population
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Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population

机译：老年人，非痴呆人群的MTA视觉评估与海马体积的比较

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Background: It is important to have a replicable easy method for monitoring atrophy progression in Alzheimer's disease. Volumetric methods for calculating hippocampal volume are time-consuming and commonly used in research. Visual assessments of medial temporal lobe atrophy (vaMTA) is a rapid method for clinical use. This method has not been tested in a large non-demented population in comparison with volumetry mesurements. Since hippocampal volume decreases with time even in normal aging there is also a need to study the normal age differences of medial temporal lobe atrophy. Purpose: To compare visual assessment of medial temporal lobe atrophy (vaMTA) with hippocampal volume in a healthy, non-demented elderly population. To describe normal ageing using vaMTA. Material and Methods: Non-demented individuals aged 60, 66, 72, 78, 81, 84, and ≥87 years old were recruited from the Swedish National study on Ageing and Care in Kungsholmen (SNAC-K), Sweden. Standard magnetic resonance imaging (MRI) scans, vaMTA, and calculations of hippocampal volumes were performed in 544 subjects. Results: Significant correlation (r s = 20.32, P 0.001, sin; and r s = 20.26, P 0.001, dx) was found between hippocampal volume measurements and vaMTA. In normal ageing, almost 95% of ≤66-year-olds had a medial temporal lobe atrophy (MTA) score ≤1, with possible scores ranging from 0 to 4. Subjects aged 72, 78, and 81 years scored ≤2, while the two oldest age groups had scores ≤3. Conclusion: There was a highly significant correlation between volumetric measurements of the hippocampus and MTA scoring. In normal ageing, there is increasing MTA score. For non-demented elderly individuals ≤70 years, an MTA score of 0-1 may be considered normal, compared with MTA ≤2 for 70-80-years and MTA 3 for 80-year-old individuals.
机译：背景：重要的是要有一种可复制的简便方法来监测阿尔茨海默氏病的萎缩进程。用于计算海马体积的体积方法耗时且在研究中通常使用。内侧颞叶萎缩症（vaMTA）的视觉评估是一种临床快速使用的方法。与量测法相比，该方法尚未在大量非痴呆人群中进行过测试。由于即使在正常衰老中海马体积也会随着时间而减少，因此还需要研究内侧颞叶萎缩的正常年龄差异。目的：比较健康，无痴呆的老年人群中颞叶萎缩（vaMTA）与海马体积的视觉评估。为了描述使用vaMTA的正常老化。材料和方法：年龄分别为60、66、72、78、81、84和≥87岁的非痴呆症患者来自瑞典国家瑞典关于Kungsholmen的衰老和护理国家研究（SNAC-K）。在544位受试者中进行了标准磁共振成像（MRI）扫描，vaMTA和海马体积的计算。结果：在海马体积测量值与vaMTA之间发现显着相关性（r s = 20.32，P <0.001，sin; r s = 20.26，P <0.001，dx）。在正常年龄中，≤95岁的人群中近95％的颞叶内侧萎缩（MTA）得分≤1，可能的得分范围为0到4。72、78和81岁的受试者得分≤2，而两个年龄最大的组的得分≤3。结论：海马体积测量与MTA评分之间存在高度显着的相关性。在正常的衰老中，MTA分数会增加。对于70岁以下≤70岁的非痴呆老年人，与70-80岁的MTA≤2和80岁以上的MTA 3相比，MTA评分0-1被认为是正常的。

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